Evidence map›Paper›PMID 25638421›Full record

ArticleFertility and sterility2015

Association of number of retrieved oocytes with live birth rate and birth weight: an analysis of 231,815 cycles of in vitro fertilization.

Valerie L Baker, Morton B Brown, Barbara Luke, Kirk P Conrad

Abstract read
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In one paragraph

Article in Fertility and sterility, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 2 pooled it
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Valerie L BakerDepartment of Obstetrics and Gynecology, Stanford University School of Medicine, Palo Alto, California. Electronic address: vlbaker@stanford.edu.
Morton B BrownDepartment of Biostatistics, University of Michigan, Ann Arbor, Michigan.
Barbara LukeDepartment of Obstetrics, Gynecology, and Reproductive Biology, College of Human Medicine, Michigan State University, East Lansing, Michigan.
Kirk P ConradDepartment of Physiology and Functional Genomics and Department of Obstetrics and Gynecology, University of Florida College of Medicine, Gainesville, Florida.

Funding

Mechanisms & Consequences of Vascular Adaptations in Pregnancies Conceived by ARTP01HD065647 · NICHD · UNIVERSITY OF FLORIDA · PI CONRAD, KIRK P · 2011 to 2016
$6.1M
NICHD NIH HHS P01 HD 065647NICHD NIH HHS P01 HD065647
6 · The paper itself

Abstract

objectiveTo determine if number of retrieved oocytes correlates with live birth rate and incidence of low birth weight (LBW).

designRetrospective cohort.

settingNot applicable. PATIENT(S): Women undergoing fresh embryo transfer with the use of either autologous (n = 194,627) or donor (n = 37,188) oocytes whose cycles were reported to the Society for Assisted Reproductive Technology in the years 2004-2010. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Live birth rate, birth weight, birth weight z-score, LBW. RESULT(S): For both autologous and donor oocyte cycles, increasing number of retrieved oocytes paralleled live birth rate and embryos available for cryopreservation in most analyses, with all models adjusted for age and previous births. For cycles achieving singleton pregnancy with the use of autologous oocytes via transfer of two embryos, a higher number of retrieved oocytes was associated with lower mean birth weight, lower birth weight z-score, and greater incidence of LBW. In contrast, for cycles using donor oocytes, there was no association of number of retrieved oocytes with measures of birth weight. CONCLUSION(S): A higher number of retrieved oocytes was associated with an increased incidence of LBW in autologous singleton pregnancies resulting from transfer of two embryos, but not in donor oocyte cycles. Although the effect of high oocyte number on the incidence of LBW in autologous cycles was of modest magnitude, further study is warranted to determine if a subgroup of women may be particularly vulnerable.

Indexed as

Birth WeightPregnancy RateCell CountCryopreservationFemaleFertilization in VitroGestational AgeHumansInfant, NewbornOocyte DonationOocyte RetrievalOocytesPregnancyPremature BirthRetrospective Studiesbirth weightIn vitro fertilizationlive birth ratelow birth weightoocyte numberz-score

Identifiers

PMID25638421
PMCPMC4415984

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.