ReviewCurrent topics in behavioral neurosciences2015
Nicotine withdrawal.
Review in Current topics in behavioral neurosciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
90 citing papers in PubMed, 6 syntheses or guidelines pooled it, 162 citations in OpenAlex.
- Exploring the Smoking-Epilepsy Nexus: a systematic review and meta-analysis of observational studies : Smoking and epilepsy.BMC medicine · 2024Pooled it
- Chronic tobacco smoking and neurocognitive impairments in adolescents and young adults: a systematic review and meta-analysis.Frontiers in psychiatry · 2024Pooled it
- Mobile Phone-Based Interventions for Smoking Cessation Among Young People: Systematic Review and Meta-Analysis.JMIR mHealth and uHealth · 2023Pooled it
- Deprivation Has Inconsistent Effects on Delay Discounting: A Review.Frontiers in behavioral neuroscience · 2022Pooled it
- Role of microRNAs in the pathophysiology of addiction.Wiley interdisciplinary reviews. RNA · 2021Pooled it
- Delay discounting of different outcomes: Review and theory.Journal of the experimental analysis of behavior · 2020Pooled it
- A multi-site study examining the tobacco withdrawal trajectory in people with tobacco and cannabis co-use.Drug and alcohol dependence · 2025Trial
- Effects of Biperiden (Cholinergic Muscarinic m1/m4 Receptor Antagonist) on Craving Nicotine: A Proof-Of-Concept Clinical Study.European addiction research · 2025Trial
- Correlates of nicotine withdrawal severity in smokers during a smoke-free psychiatric hospitalization.Preventive medicine · 2016Trial
- Impact of Maternal Smoking During Pregnancy on Fetal and Neonatal Neurobehavioral Development: A Narrative Review.Rhode Island medical journal (2013) · 2026Review
- Narrative Review of Novel Nicotine-Delivery Systems and Emerging Pharmaceuticals for Tobacco Cessation.Medicines (Basel, Switzerland) · 2026Review
- Pilot trial of delayed versus immediate financial incentives for smoking cessation.Contemporary clinical trials communications · 2026Article
- Acute Nicotine Poisoning From Nicotine Pouch Use in Adolescents: A Case Report of Two Pediatric Cases.Cureus · 2026Article
- Review
- The Role of Sleep Impairment in Associations Between Pain and Nicotine/Tobacco Dependence in Wave 6 of the Population Assessment of Tobacco and Health (PATH) Study.Substance use & misuse · 2026Article
- The relationship between nicotine craving and state anxiety in daily and non-daily nicotine users.Addictive behaviors · 2026Article
- Chemogenetic control of GABAergic neurons within the interpeduncular nucleus reveals dissociable behavioral components of the nicotine withdrawal phenotype.Neurobiology of disease · 2026Article
- The Fagerström Test for Nicotine Dependence-Smokeless Tobacco: Exploring the Intricate Relationship between Smokeless Tobacco Dependence and Periodontal Status.International journal of preventive medicine · 2026Article
- Harmonizing mind acupuncture combined with nicotine replacement therapy for tobacco use disorder: a protocol for a pragmatic randomized controlled trial.Frontiers in public health · 2026Article
- Assessment of alcohol and tobacco use in psychotherapy: validation of the german self-report ASSIST alcohol and tobacco subscales in an outpatient setting.Addictive behaviors reports · 2025Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
An aversive abstinence syndrome manifests 4-24 h following cessation of chronic use of nicotine-containing products. Symptoms peak on approximately the 3rd day and taper off over the course of the following 3-4 weeks. While the severity of withdrawal symptoms is largely determined by how nicotine is consumed, certain short nucleotide polymorphisms (SNPs) have been shown to predispose individuals to consume larger amounts of nicotine more frequently--as well as to more severe symptoms of withdrawal when trying to quit. Additionally, rodent behavioral models and transgenic mouse models have revealed that specific nicotinic acetylcholine receptor (nAChR) subunits, cellular components, and neuronal circuits are critical to the expression of withdrawal symptoms. Consequently, by continuing to map neuronal circuits and nAChR subpopulations that underlie the nicotine withdrawal syndrome--and by continuing to enumerate genes that predispose carriers to nicotine addiction and exacerbated withdrawal symptoms--it will be possible to pursue personalized therapeutics that more effectively treat nicotine addiction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.