Evidence map›Paper›PMID 25637854›Full record

ReviewVision research2015

Stereopsis and amblyopia: A mini-review.

Dennis M Levi, David C Knill, Daphne Bavelier

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Vision research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04315649 (Effect of 3D Movie Viewing on Stereopsis in Strabismus and / or Anisometropic Amblyops), which is not on this map. Cited by 208 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
208citing papers in PubMed, 5 pooled it
12.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04315649 nacompletednot on this mapstarted 2021, after this paper: background citation

Effect of 3D Movie Viewing on Stereopsis in Strabismus and / or Anisometropic Amblyops

TypeinterventionalSponsorUniversitat Politècnica de CatalunyaRan2021 to 2022Enrolled24ConditionsAmblyopia, Anisometropic Amblyopia, Strabismic AmblyopiaArms3D movie viewing
3 · Its place in the literature

Who cites it

208 citing papers in PubMed, 5 syntheses or guidelines pooled it, 400 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Guideline
  4. Amblyopia: progress and promise of functional magnetic resonance imaging.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023
    Pooled it
  5. Pooled it
  6. Efficacy of patching combined with action video games in amblyopic children aged 4-10 years: A randomised clinical trial.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025
    Trial
  7. Randomised trial of three treatments for amblyopia: Vision therapy and patching, perceptual learning and patching alone.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025
    Trial
  8. Trial
  9. Trial
  10. Trial
  11. Barriers to successful dichoptic treatment for amblyopia in young children.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021
    Trial
  12. Trial
  13. Trial
  14. Article
  15. Article
  16. Article
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  20. Article

148 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Dennis M LeviSchool of Optometry, Graduate Group in Vision Science and Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720-2020, USA. Electronic address: dlevi@berkeley.edu.
David C KnillDepartment of Brain & Cognitive Sciences, University of Rochester, Rochester, NY 14627-0268, USA; Center for Visual Science, University of Rochester, Rochester, NY 14627-0268, USA.
Daphne BavelierDepartment of Brain & Cognitive Sciences, University of Rochester, Rochester, NY 14627-0268, USA; Center for Visual Science, University of Rochester, Rochester, NY 14627-0268, USA; Psychology and Education Sciences (FPSE), University of Geneva, Geneva, Switzerland.
University of California, Berkeley · USUniversity of Geneva · CHUniversity of Rochester · US

Funding

A New Approach to Restoring Visual Acuity and Stereopsis in Adults with AmblyopiaR01EY020976 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI BANKS, MARTIN S, BAVELIER, DAPHNE I · 2010 to 2020
$4.7M
Visual Learning: the case of video gamesR01EY016880 · NEI · UNIVERSITY OF ROCHESTER · PI BAVELIER, DAPHNE I · 2005 to 2009
$1.8M
NEI NIH HHS R01 EY016880NEI NIH HHS R01EY016880NEI NIH HHS R01 EY020976NEI NIH HHS R01EY020976
6 · The paper itself

Abstract

Amblyopia is a neuro-developmental disorder of the visual cortex that arises from abnormal visual experience early in life. Amblyopia is clinically important because it is a major cause of vision loss in infants and young children. Amblyopia is also of basic interest because it reflects the neural impairment that occurs when normal visual development is disrupted. Amblyopia provides an ideal model for understanding when and how brain plasticity may be harnessed for recovery of function. Over the past two decades there has been a rekindling of interest in developing more effective methods for treating amblyopia, and for extending the treatment beyond the critical period, as exemplified by new clinical trials and new basic research studies. The focus of this review is on stereopsis and its potential for recovery. Impaired stereoscopic depth perception is the most common deficit associated with amblyopia under ordinary (binocular) viewing conditions (Webber & Wood, 2005). Our review of the extant literature suggests that this impairment may have a substantial impact on visuomotor tasks, difficulties in playing sports in children and locomoting safely in older adults. Furthermore, impaired stereopsis may also limit career options for amblyopes. Finally, stereopsis is more impacted in strabismic than in anisometropic amblyopia. Our review of the various approaches to treating amblyopia (patching, perceptual learning, videogames) suggests that there are several promising new approaches to recovering stereopsis in both anisometropic and strabismic amblyopes. However, recovery of stereoacuity may require more active treatment in strabismic than in anisometropic amblyopia. Individuals with strabismic amblyopia have a very low probability of improvement with monocular training; however they fare better with dichoptic training than with monocular training, and even better with direct stereo training.

Indexed as

AdultAge FactorsAmblyopiaAnisometropiaChildDepth PerceptionHumansStrabismusVision, BinocularVisual AcuityAmblyopiaAnisometropiaPerceptual learningStereopsisStrabismusVideogames

Identifiers

PMID25637854
PMCPMC4519435
OpenAlexW2039406936

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.