ArticleAmerican journal of obstetrics and gynecology2015
Identification of a gene in Mycoplasma hominis associated with preterm birth and microbial burden in intraamniotic infection.
Article in American journal of obstetrics and gynecology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 69 citations in OpenAlex.
- Intra-amniotic infection: diagnosis, nomenclature, clinical significance, management, and microbiologic tools used for the diagnosis.Clinical microbiology reviews · 2026Review
- Gestational Age-Dependent Associations Between Mycoplasma/Ureaplasma Colonization and Inflammatory Placental Lesions in Preterm Birth.Journal of clinical medicine · 2026Article
- A genome-wide investigation ofFrontiers in microbiology · 2025Article
- Molecular evidence that GBS early neonatal sepsis results from ascending infection: comparative hybrid genomics analyses show that microorganisms in the vaginal ecosystem, amniotic fluid, chorioamniotic membranes, and neonatal blood are the same.Journal of perinatal medicine · 2024Article
- Review
- Detection of Putative Virulence GenesInternational journal of molecular sciences · 2023Article
- Application of next-generation sequencing on diagnosis of bloodstream infection caused by Mycoplasma hominis in a patient with ANCA-associated vasculitis.Annals of clinical microbiology and antimicrobials · 2023Article
- The Prevalence of Genital Mycoplasmas and Coinfection withMicroorganisms · 2023Article
- Prevalence of selected sexually transmitted infectious agents in a cohort of asymptomatic soldiers in Austria.Parasites & vectors · 2022Article
- The associations between low abundance of Mycoplasma hominis and female fecundability: a pregnancy-planning cohort study.BMC microbiology · 2022Article
- Bacteria in the amniotic fluid without inflammation: early colonization vs. contamination.Journal of perinatal medicine · 2021Article
- Article
- Paradigms of Protist/Bacteria Symbioses Affecting Human Health:Frontiers in microbiology · 2020Review
- Article
- Impact of Symbiosis BetweenFrontiers in cellular and infection microbiology · 2020Review
- Evidence that intra-amniotic infections are often the result of an ascending invasion - a molecular microbiological study.Journal of perinatal medicine · 2019Article
- The origin of amniotic fluid monocytes/macrophages in women with intra-amniotic inflammation or infection.Journal of perinatal medicine · 2019Article
- Random transposon insertion in the Mycoplasma hominis minimal genome.Scientific reports · 2019Article
- Does the human placenta delivered at term have a microbiota? Results of cultivation, quantitative real-time PCR, 16S rRNA gene sequencing, and metagenomics.American journal of obstetrics and gynecology · 2019Article
- The frequency and clinical significance of intra-amniotic inflammation in twin pregnancies with preterm labor and intact membranes.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2019Observational
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveMicrobial invasion of the amniotic cavity is associated with spontaneous preterm labor and adverse pregnancy outcome, and Mycoplasma hominis often is present. However, the pathogenic process by which M hominis invades the amniotic cavity and gestational tissues, often resulting in chorioamnionitis and preterm birth, remains unknown. We hypothesized that strains of M hominis vary genetically with regards to their potential to invade and colonize the amniotic cavity and placenta. STUDY
designWe sequenced the entire genomes of 2 amniotic fluid isolates and a placental isolate of M hominis from pregnancies that resulted in preterm births and compared them with the previously sequenced genome of the type strain PG21. We identified genes that were specific to the amniotic fluid/placental isolates. We then determined the microbial burden and the presence of these genes in another set of subjects from whom samples of amniotic fluid had been collected and were positive for M hominis.
resultsWe identified 2 genes that encode surface-located membrane proteins (Lmp1 and Lmp-like) in the sequenced amniotic fluid/placental isolates that were truncated severely in PG21. We also identified, for the first time, a microbial gene of unknown function that is referred to in this study as gene of interest C that was associated significantly with bacterial burden in amniotic fluid and the risk of preterm delivery in patients with preterm labor.
conclusionA gene in M hominis was identified that is associated significantly with colonization and/or infection of the upper reproductive tract during pregnancy and with preterm birth.
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