ArticleNeuroscience2015
μ and κ opioid receptor distribution in the monogamous titi monkey (Callicebus cupreus): implications for social behavior and endocrine functioning.
Article in Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 35 citations in OpenAlex.
- Article
- Article
- Efficacy and safety of anrikefon injection for postoperative analgesia in specific patient groups (elderly, liver damage, renal damage) after abdominal surgery.Journal of anesthesia and translational medicine · 2024Article
- Oxytocin: A developmental journey.Comprehensive psychoneuroendocrinology · 2023Review
- Intranasal oxytocin does not change partner preference in female titi monkeys (Plecturocebus cupreus), but intranasal vasopressin decreases it.Journal of neuroendocrinology · 2023Article
- Interactions between thePhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Interplay between the oxytocin and opioid systems in regulating social behaviour.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Using Receptor Autoradiography to Visualize and Quantify Oxytocin and Vasopressin 1a Receptors in the Human and Nonhuman Primate Brain.Methods in molecular biology (Clifton, N.J.) · 2022Article
- The neural circuits of monogamous behavior.Frontiers in neural circuits · 2022Review
- Pharmacokinetic neuroimaging to study the dose-related brain kinetics and target engagement of buprenorphine in vivo.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Antinociceptive and Antipruritic Effects of HSK21542, a Peripherally-Restricted Kappa Opioid Receptor Agonist, in Animal Models of Pain and Itch.Frontiers in pharmacology · 2021Article
- Coppery titi monkey (Plecturocebus cupreus) pairs display coordinated behaviors in response to a simulated intruder.American journal of primatology · 2020Article
- The amygdalar opioid system.Handbook of behavioral neuroscience · 2020Article
- Development and In Vivo Evaluation of a κ-Opioid Receptor Agonist as a PET Radiotracer with Superior Imaging Characteristics.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2019Article
- Radiosynthesis of [ACS medicinal chemistry letters · 2018Article
- Effects of aggressive temperament on endogenous oxytocin levels in adult titi monkeys.American journal of primatology · 2018Article
- μ opioid receptor, social behaviour and autism spectrum disorder: reward matters.British journal of pharmacology · 2018Review
- Robust age, but limited sex, differences in mu-opioid receptors in the rat brain: relevance for reward and drug-seeking behaviors in juveniles.Brain structure & function · 2018Article
- Imaging, Behavior and Endocrine Analysis of "Jealousy" in a Monogamous Primate.Frontiers in ecology and evolution · 2017Article
- Titi Monkeys as a Novel Non-Human Primate Model for the Neurobiology of Pair Bonding .The Yale journal of biology and medicine · 2017Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The opioid system is involved in infant-mother bonds and adult-adult bonds in many species. We have previously shown that μ opioid receptors (MORs) and κ opioid receptors (KORs) are involved in regulating the adult attachment of the monogamous titi monkey. The present study sought to determine the distribution of MOR and KOR in the titi monkey brain using receptor autoradiography. We used [(3)H][D-Ala(2),N-Me-Phe(4),Gly(5)-ol]-enkephalin (DAMGO) to label MORs and [(3)H]U69,593 to label KORs. MOR binding was heterogeneous throughout the titi monkey brain. Specifically, MOR binding was observed in the cingulate gyrus (CG), striatum, septal regions, diagonal band, amygdala, hypothalamus, hippocampus, and thalamus. Binding was particularly dense in the septum, medial amygdala, paraventricular nucleus of the hypothalamus, mediodorsal thalamus with moderate binding in the nucleus accumbens. Consistent with other primate species, MOR were also observed in "neurochemically unique domains of the accumbens and putamen" (NUDAPs). In general KOR binding was more homogenous. KORs were primarily found in the CG, striatum, amygdala and hippocampus. Dense KOR binding was observed in the claustrum. Relative MOR and KOR binding in the titi monkey striatum was similar to other humans and primates, but was much lower compared to rodents. Relative MOR binding in the titi monkey hypothalamus was much greater than that found in rodents. This study was the first to examine MOR and KOR binding in a monogamous primate. The location of these receptors gives insight into where ligands may be acting to regulate social behavior and endocrine function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.