Evidence map›Paper›PMID 25637710›Full record

ArticleAntiviral research2015

Heparin octasaccharide decoy liposomes inhibit replication of multiple viruses.

Gabriel L Hendricks, Lourdes Velazquez, Serena Pham, Natasha Qaisar, James C Delaney, Karthik Viswanathan, Leila Albers, James C Comolli, Zachary Shriver, David M Knipe and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antiviral research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 36 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Gabriel L HendricksDepartment of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, United States.
Lourdes VelazquezDepartment of Physics, Broida Hall, University of California, Santa Barbara, CA 93106, United States.
Serena PhamDepartment of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, United States.
Natasha QaisarDepartment of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, United States.
James C DelaneyDepartment of Biological Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02142, United States.
Karthik ViswanathanDepartment of Biological Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02142, United States.
Leila AlbersCharles Stark Draper Laboratory, Department of Bioengineering, 555 Technology Square, Cambridge, MA 02139, United States.
James C ComolliCharles Stark Draper Laboratory, Department of Bioengineering, 555 Technology Square, Cambridge, MA 02139, United States.
Zachary ShriverDepartment of Biological Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02142, United States.
David M KnipeDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, United States.
Evelyn A Kurt-JonesDepartment of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, United States.
Deborah K FygensonDepartment of Physics, Broida Hall, University of California, Santa Barbara, CA 93106, United States.
Jose M TrevejoCharles Stark Draper Laboratory, Department of Bioengineering, 555 Technology Square, Cambridge, MA 02139, United States.
Jennifer P Wang *Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, United States.
Robert W Finberg *Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, United States.
University of Massachusetts Chan Medical School · USDraper Laboratory · USMassachusetts Institute of Technology · USUniversity of California, Santa Barbara · USHarvard University · US

Funding

Genetics of Herpesvirus TransformationR01AI063106 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI KNIPE, DAVID M. · 2004 to 2013
$3.8M
NIAID NIH HHS AI063106NIAID NIH HHS R01 AI063106
6 · The paper itself

Abstract

Heparan sulfate (HS) is a ubiquitous glycosaminoglycan that serves as a cellular attachment site for a number of significant human pathogens, including respiratory syncytial virus (RSV), human parainfluenza virus 3 (hPIV3), and herpes simplex virus (HSV). Decoy receptors can target pathogens by binding to the receptor pocket on viral attachment proteins, acting as 'molecular sinks' and preventing the pathogen from binding to susceptible host cells. Decoy receptors functionalized with HS could bind to pathogens and prevent infection, so we generated decoy liposomes displaying HS-octasaccharide (HS-octa). These decoy liposomes significantly inhibited RSV, hPIV3, and HSV infectivity in vitro to a greater degree than the original HS-octa building block. The degree of inhibition correlated with the density of HS-octa displayed on the liposome surface. Decoy liposomes with HS-octa inhibited infection of viruses to a greater extent than either full-length heparin or HS-octa alone. Decoy liposomes were effective when added prior to infection or following the initial infection of cells in vitro. By targeting the well-conserved receptor-binding sites of HS-binding viruses, decoy liposomes functionalized with HS-octa are a promising therapeutic antiviral agent and illustrate the utility of the liposome delivery platform.

Indexed as

LiposomesAnimalsAntiviral AgentsHeparan SulfateParainfluenza Virus 3, HumanRespiratory Syncytial VirusesSimplexvirusVero CellsVirus ReplicationAntiviral AgentsHeparan SulfateLiposomesDecoyHeparinHerpes simplex virusLiposomeParainfluenza virusRespiratory syncytial virus

Identifiers

PMID25637710
PMCPMC4988063
OpenAlexW2024949431

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.