Evidence map›Paper›PMID 25637700›Full record

ArticleNeuroscience letters2015

Neonatal handling (resilience) attenuates water-avoidance stress induced enhancement of chronic mechanical hyperalgesia in the rat.

Pedro Alvarez, Jon D Levine, Paul G Green

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Sex differences in the transition to chronic pain.The Journal of clinical investigation · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Pedro AlvarezDepartments of Oral and Maxillofacial Surgery, University of California, San Francisco, USA; Division of Neuroscience, University of California, San Francisco, USA.
Jon D LevineDepartments of Oral and Maxillofacial Surgery, University of California, San Francisco, USA; Departments of Medicine, University of California, San Francisco, USA; Division of Neuroscience, University of California, San Francisco, USA. Electronic address: jon.levine@ucsf.edu.
Paul G GreenDepartments of Oral and Maxillofacial Surgery, University of California, San Francisco, USA; Division of Neuroscience, University of California, San Francisco, USA.
University of California, San Francisco · US

Funding

Acute-to-Chronic Transition in Ergonomic Muscle Pain: Nociceptor MechanismsR01AR063312 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEVINE, JON DAVID · 2013 to 2022
$6.5M
NIAMS NIH HHS AR063312NIAMS NIH HHS R01 AR063312
6 · The paper itself

Abstract

Chronic stress is well known to exacerbate pain. We tested the hypothesis that neonatal handling, which induces resilience to the negative impact of stress by increasing the quality and quantity of maternal care, attenuates the mechanical hyperalgesia produced by water-avoidance stress in the adult rat. Neonatal male rats underwent the handling protocol on postnatal days 2-9, weaned at 21 days and tested for muscle mechanical nociceptive threshold at postnatal days 50-75. Decrease in mechanical nociceptive threshold in skeletal muscle in adult rats, produced by exposure to water-avoidance stress, was significantly attenuated by neonatal handling. Neonatal handling also attenuated the mechanical hyperalgesia produced by intramuscular administration of the pronociceptive inflammatory mediator, prostaglandin E2 in rats exposed as adults to water-avoidance stress. Neonatal handling, which induces a smaller corticosterone response in adult rats exposed to a stressor as well as changes in central nervous system neurotransmitter systems, attenuates mechanical hyperalgesia produced by water-avoidance stress and enhanced prostaglandin hyperalgesia in adult animals.

Indexed as

Handling, PsychologicalAnimalsChronic DiseaseHyperalgesiaMaleMuscle, SkeletalPain ThresholdPhysical StimulationRats, Sprague-DawleyStress, PsychologicalHousing densityMuscle hyperalgesiaNeonatal handlingResilienceStress

Identifiers

PMID25637700
PMCPMC4711809
OpenAlexW1964024372

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.