ArticleBehavior genetics2015
Genome-Wide Association Study of Behavioral Disinhibition in a Selected Adolescent Sample.
Article in Behavior genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-Analyses of Genome-Wide Association Data Hold New Promise for Addiction Genetics.Journal of studies on alcohol and drugs · 2016Pooled it
- Developmental genetic effects on externalizing behavior and alcohol use: Examination across two longitudinal samples.Development and psychopathology · 2024Article
- Polygenic Effects on Individual Rule Breaking, Peer Rule Breaking, and Alcohol Sips Across Early Adolescence in the ABCD Study.Research on child and adolescent psychopathology · 2023Article
- Detection of Parent-of-Origin Effects for the Variants Associated With Behavioral Disinhibition in the MCTFR Data.Frontiers in genetics · 2022Article
- Polygenic Risk for Aggression Predicts Adult Substance Use Disorder Diagnoses via Substance Use Offending in Emerging Adulthood and is Moderated by a Family-Centered Intervention.Behavior genetics · 2021Article
- A statistical measure for the skewness of X chromosome inactivation for quantitative traits and its application to the MCTFR data.BMC genomic data · 2021Article
- Phenotypic and genetic markers of psychopathology in a population-based sample of older adults.Translational psychiatry · 2021Article
- Heritability of overlapping impulsivity and compulsivity dimensional phenotypes.Scientific reports · 2020Article
- Adolescent Externalizing Psychopathology and Its Prospective Relationship to Marijuana Use Development from Age 14 to 30: Replication Across Independent Longitudinal Twin Samples.Behavior genetics · 2020Article
- Imputation of behavioral candidate gene repeat variants in 486,551 publicly-available UK Biobank individuals.European journal of human genetics : EJHG · 2019Article
- No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples.The American journal of psychiatry · 2019Article
- Predictors of reduced smoking quantity among recovering alcohol dependent men in a smoking cessation trial.Addictive behaviors · 2018Article
- The utility of twins in developmental cognitive neuroscience research: How twins strengthen the ABCD research design.Developmental cognitive neuroscience · 2018Review
- Positive expectancies mediate the association between sensation seeking and marijuana outcomes in at-risk young adults: A test of the acquired preparedness model.The American journal on addictions · 2018Article
- Cannabis use disorder and male sex predict medical cannabis card status in a sample of high risk adolescents.Drug and alcohol dependence · 2018Article
- Impulsivity Dimensions and Risky Sex Behaviors in an At-Risk Young Adult Sample.Archives of sexual behavior · 2018Article
- Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior.JAMA psychiatry · 2017Article
- Genetic influences on the human oral microbiome.BMC genomics · 2017Article
- Unique and interactive effects of impulsivity facets on reckless driving and driving under the influence in a high-risk young adult sample.Personality and individual differences · 2017Article
- Using Patterns of Genetic Association to Elucidate Shared Genetic Etiologies Across Psychiatric Disorders.Behavior genetics · 2017Article
Corrections and comments
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Authors and funding
19 authors.
Funding
Abstract
Behavioral disinhibition (BD) is a quantitative measure designed to capture the heritable variation encompassing risky and impulsive behaviors. As a result, BD represents an ideal target for discovering genetic loci that predispose individuals to a wide range of antisocial behaviors and substance misuse that together represent a large cost to society as a whole. Published genome-wide association studies (GWAS) have examined specific phenotypes that fall under the umbrella of BD (e.g. alcohol dependence, conduct disorder); however no GWAS has specifically examined the overall BD construct. We conducted a GWAS of BD using a sample of 1,901 adolescents over-selected for characteristics that define high BD, such as substance and antisocial behavior problems, finding no individual locus that surpassed genome-wide significance. Although no single SNP was significantly associated with BD, restricted maximum likelihood analysis estimated that 49.3 % of the variance in BD within the Caucasian sub-sample was accounted for by the genotyped SNPs (p = 0.06). Gene-based tests identified seven genes associated with BD (p ≤ 2.0 × 10(-6)). Although the current study was unable to identify specific SNPs or pathways with replicable effects on BD, the substantial sample variance that could be explained by all genotyped SNPs suggests that larger studies could successfully identify common variants associated with BD.
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