ArticleAdvances in pharmacology (San Diego, Calif.)2015
GABAergic control of depression-related brain states.
Article in Advances in pharmacology (San Diego, Calif.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
90 citing papers in PubMed, 1 synthesis or guideline pooled it, 145 citations in OpenAlex.
- Absence seizures and their relationship to depression and anxiety: Evidence for bidirectionality.Epilepsia · 2021Pooled it
- High-dose Vitamin-B6 reduces sensory over-responsivity.Journal of psychopharmacology (Oxford, England) · 2024Trial
- High-dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression.Human psychopharmacology · 2022Trial
- Thalamic Gamma Aminobutyric Acid Level Changes in Major Depressive Disorder After a 12-Week Iyengar Yoga and Coherent Breathing Intervention.Journal of alternative and complementary medicine (New York, N.Y.) · 2020Trial
- SAGE-217, A Novel GABAClinical pharmacokinetics · 2020Trial
- Transcriptome changes of disinhibited somatostatin neurons in the medial prefrontal cortex mediating male-specific stress resilience.Research square · 2026Article
- Improved subjective sleep quality in older adults by enhancing the GABAergic system in the sensorimotor cortex.The Journal of physiology · 2026Article
- AMPA receptor modulation in depression: from molecular mechanisms of plasticity to therapeutic translation.Pharmacological reports : PR · 2026Review
- Ionic Homeostasis Failure in Major Depressive Disorder: Ion Channel Mechanisms, Excitation-Inhibition Imbalance, and Precision Therapeutics.International journal of molecular sciences · 2026Review
- IL-17A in the hippocampus regulates despair-like behaviors via inhibitory synaptic transmission.Acta pharmacologica Sinica · 2026Article
- Knockout of α-Synuclein Is Associated with Depression-like Behaviors by Altered Excitability of Medial Prefrontal Cortex Neurons in Mice.International journal of molecular sciences · 2026Article
- A depression-like phenotype is associated with discrete defects in the primary hippocampal circuit.Translational psychiatry · 2026Article
- TheFoods (Basel, Switzerland) · 2026Article
- Kynurenine pathway dysregulation in major depressive disorder: the convergence of excitotoxicity, neuroinflammation, and oxidative stress.Journal of neuroinflammation · 2026Review
- Evaluation of the therapeutic efficacy of the dextromethorphan-bupropion combination and its mediating pathways in a mouse model of major depressive disorder.Frontiers in pharmacology · 2026Article
- Neuroimmune Interactions in Stress and Depression: Exploring the Molecular and Cellular Mechanisms within the Neuroinflammation-depression Nexus.Current medicinal chemistry · 2026Review
- Evolutionary dynamics and transcriptional diversification of GAD gene family in plants: a pan-species perspective in silico analysis.BMC plant biology · 2025Article
- The delta/alpha ratio in sleep EEG increases with the severity of depression in patients over 50 years old.BMC psychiatry · 2025Article
- Brain structural and functional aberrant of hippocampal subregions was associated with somatic depression.BMC psychiatry · 2025Article
- Peripartum Depression Pharmacotherapies Targeting GABA-Glutamate Neurotransmission.Journal of clinical medicine · 2025Review
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The GABAergic deficit hypothesis of major depressive disorders (MDDs) posits that reduced γ-aminobutyric acid (GABA) concentration in brain, impaired function of GABAergic interneurons, altered expression and function of GABA(A) receptors, and changes in GABAergic transmission dictated by altered chloride homeostasis can contribute to the etiology of MDD. Conversely, the hypothesis posits that the efficacy of currently used antidepressants is determined by their ability to enhance GABAergic neurotransmission. We here provide an update for corresponding evidence from studies of patients and preclinical animal models of depression. In addition, we propose an explanation for the continued lack of genetic evidence that explains the considerable heritability of MDD. Lastly, we discuss how alterations in GABAergic transmission are integral to other hypotheses of MDD that emphasize (i) the role of monoaminergic deficits, (ii) stress-based etiologies, (iii) neurotrophic deficits, and (iv) the neurotoxic and neural circuit-impairing consequences of chronic excesses of glutamate. We propose that altered GABAergic transmission serves as a common denominator of MDD that can account for all these other hypotheses and that plays a causal and common role in diverse mechanistic etiologies of depressive brain states and in the mechanism of action of current antidepressant drug therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.