ArticleAge (Dordrecht, Netherlands)2015
Genetics of hand grip strength in mid to late life.
Article in Age (Dordrecht, Netherlands), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Article
- Correlates of hand grip strength in a cohort of older Nigerian Africans: Findings from the population-based VALIANT project.The Journal of frailty & aging · 2025Article
- A GWAS for grip strength in cohorts of children-Advantages of analysing young participants for this trait.Genes, brain, and behavior · 2024Article
- Population Norms for Hand Grip and Precision Grip Strengths in Polish Children and Adolescents Aged 3-19.Journal of clinical medicine · 2024Article
- Lifetime serum concentration of 25-hydroxyvitamin D 25(OH) is associated with hand grip strengths: insight from a Mendelian randomisation.Age and ageing · 2022Article
- The genetics of human performance.Nature reviews. Genetics · 2022Review
- The Relationship between Health Perception and Health Predictors among the Elderly across European Countries.International journal of environmental research and public health · 2021Article
- Epigenome-wide exploratory study of monozygotic twins suggests differentially methylated regions to associate with hand grip strength.Biogerontology · 2019Article
- Grip Strength as an Indicator of Health-Related Quality of Life in Old Age-A Pilot Study.International journal of environmental research and public health · 2017Article
- Cross-sectional relations of whole-blood miRNA expression levels and hand grip strength in a community sample.Aging cell · 2017Article
- Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness.Nature communications · 2017Article
- Prospective Associations of Low Muscle Mass and Function with 10-Year Falls Risk, Incident Fracture and Mortality in Community-Dwelling Older Adults.The journal of nutrition, health & aging · 2017Article
- A multilevel analysis of health-related physical fitness. The Portuguese sibling study on growth, fitness, lifestyle and health.PloS one · 2017Article
Corrections and comments
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Authors and funding
19 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hand grip strength (GS) is a predictor of mortality in older adults and is moderately to highly heritable, but no genetic variants have been consistently identified. We aimed to identify single nucleotide polymorphisms (SNPs) associated with GS in middle-aged to older adults using a genome-wide association study (GWAS). GS was measured using handheld dynamometry in community-dwelling men and women aged 55-85 from the Hunter Community Study (HCS, N = 2088) and the Sydney Memory and Ageing Study (Sydney MAS, N = 541). Genotyping was undertaken using Affymetrix microarrays with imputation to HapMap2. Analyses were performed using linear regression. No genome-wide significant results were observed in HCS nor were any of the top signals replicated in Sydney MAS. Gene-based analyses in HCS identified two significant genes (ZNF295, C2CD2), but these results were not replicated in Sydney MAS. One out of eight SNPs previously associated with GS, rs550942, located near the CNTF gene, was significantly associated with GS (p = 0.005) in the HCS cohort only. Study differences may explain the lack of consistent results between the studies, including the smaller sample size of the Sydney MAS cohort. Our modest sample size also had limited power to identify variants of small effect. Our results suggest that similar to various other complex traits, many genetic variants of small effect size may influence GS. Future GWAS using larger samples and consistent measures may prove more fruitful at identifying genetic contributors for GS in middle-aged to older adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.