ArticleFEBS letters2015
An evolutionarily-unique heterodimeric voltage-gated cation channel found in aphids.
Article in FEBS letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 28 citations in OpenAlex.
- Spread of a Single Superclone Drives Insecticide Resistance in Acyrthosiphon kondoi Across an Invasive Range.Molecular biology and evolution · 2025Article
- Exploring Flexibility and Folding Patterns Throughout Time in Voltage Sensors.Journal of molecular evolution · 2023Article
- Transposon-mediated insertional mutagenesis unmasks recessive insecticide resistance in the aphidProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Distinct functional properties of sodium channel variants are associated with usage of alternative exons in Nilaparvata lugens.Insect biochemistry and molecular biology · 2020Article
- RNA interference-mediated knockdown of voltage-gated sodium channel (MpNaScientific reports · 2019Article
- Article
- Voltage-gated sodium channels as targets for pyrethroid insecticides.European biophysics journal : EBJ · 2017Review
- Isolated pores dissected from human two-pore channel 2 are functional.Scientific reports · 2016Article
- Expression patterns, mutation detection and RNA interference of Rhopalosiphum padi voltage-gated sodium channel genes.Scientific reports · 2016Article
- Molecular basis of ion permeability in a voltage-gated sodium channel.The EMBO journal · 2016Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
We describe the identification in aphids of a unique heterodimeric voltage-gated sodium channel which has an atypical ion selectivity filter and, unusually for insect channels, is highly insensitive to tetrodotoxin. We demonstrate that this channel has most likely arisen by adaptation (gene fission or duplication) of an invertebrate ancestral mono(hetero)meric channel. This is the only identifiable voltage-gated sodium channel homologue in the aphid genome(s), and the channel's novel selectivity filter motif (DENS instead of the usual DEKA found in other eukaryotes) may result in a loss of sodium selectivity, as indicated experimentally in mutagenised Drosophila channels.
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