ArticleJournal of immunology (Baltimore, Md. : 1950)2015
Cell-autonomous sex differences in gene expression in chicken bone marrow-derived macrophages.
Article in Journal of immunology (Baltimore, Md. : 1950), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- Hens and roosters of two distinct lines differ in immune cell profiles.Poultry science · 2026Article
- Mechanistic understanding of female reproductive aging based on the chicken model.Journal of animal science and biotechnology · 2026Review
- Modulation of alveolar macrophages by sex as a biological variable.American journal of physiology. Lung cellular and molecular physiology · 2026Article
- Integrated analysis of sex differences in human dendritic cell, monocyte, and natural killer cell subsets.Frontiers in immunology · 2026Article
- Chromosome-level reference genome assembly of the gyrfalcon (Falco rusticolus) and population genomics offer insights into the falcon population in Mongolia.Scientific reports · 2025Article
- Role of sex as a biological variable in neonatal alveolar macrophages.Redox biology · 2024Article
- Phenotypic and genomic characterisation of performance of tropically adapted chickens raised in smallholder farm conditions in Ethiopia.Frontiers in genetics · 2024Article
- Development and function of chicken XCR1Frontiers in immunology · 2023Article
- Genetic variation in chicken interferon signalling pathway genes in research lines showing differential viral resistance.Animal genetics · 2022Article
- Crosstalk between dihydroceramides produced by Porphyromonas gingivalis and host lysosomal cathepsin B in the promotion of osteoclastogenesis.Journal of cellular and molecular medicine · 2022Article
- The Outer Membrane Vesicles ofPathogens (Basel, Switzerland) · 2022Article
- Sexual dimorphism of monocyte transcriptome in individuals with chronic low-grade inflammation.Biology of sex differences · 2021Article
- Seasonal variation in sex-specific immunity in wild birds.Scientific reports · 2021Article
- Quantitative trait loci and transcriptome signatures associated with avian heritable resistance to Campylobacter.Scientific reports · 2021Article
- An integrated transcriptomics and metabolomics study of the immune response of newly hatched chicks to the cytosine-phosphate-guanine oligonucleotide stimulation.Poultry science · 2020Article
- Regulation and function of macrophage colony-stimulating factor (CSF1) in the chicken immune system.Developmental and comparative immunology · 2020Article
- ImmGen report: sexual dimorphism in the immune system transcriptome.Nature communications · 2019Article
- Released Tryptophanyl-tRNA Synthetase Stimulates Innate Immune Responses against Viral Infection.Journal of virology · 2019Article
- Analysis of the Progeny of Sibling Matings Reveals Regulatory Variation Impacting the Transcriptome of Immune Cells in Commercial Chickens.Frontiers in genetics · 2019Article
- Combination of novel and public RNA-seq datasets to generate an mRNA expression atlas for the domestic chicken.BMC genomics · 2018Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
We have identified differences in gene expression in macrophages grown from the bone marrow of male and female chickens in recombinant chicken M-CSF (CSF1). Cells were profiled with or without treatment with bacterial LPS for 24 h. Approximately 600 transcripts were induced by prolonged LPS stimulation to an equal extent in the male and female macrophages. Many transcripts encoded on the Z chromosome were expressed ∼1.6-fold higher in males, reflecting a lack of dosage compensation in the homogametic sex. A smaller set of W chromosome-specific genes was expressed only in females. LPS signaling in mammals is associated with induction of type 1 IFN-responsive genes. Unexpectedly, because IFNs are encoded on the Z chromosome of chickens, unstimulated macrophages from the female birds expressed a set of known IFN-inducible genes at much higher levels than male cells under the same conditions. To confirm that these differences were not the consequence of the actions of gonadal hormones, we induced gonadal sex reversal to alter the hormonal environment of the developing chick and analyzed macrophages cultured from male, female, and female sex-reversed embryos. Gonadal sex reversal did not alter the sexually dimorphic expression of either sex-linked or IFN-responsive genes. We suggest that female birds compensate for the reduced dose of inducible IFN with a higher basal set point of IFN-responsive genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.