Evidence map›Paper›PMID 25637011›Full record

ReviewJournal of chromatography. A2015

A review of microdialysis coupled to microchip electrophoresis for monitoring biological events.

Rachel A Saylor, Susan M Lunte

Abstract readReview
In one paragraph

Review in Journal of chromatography. A, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. A Unified Analytical Method Greenness Score (ACS sustainable chemistry & engineering · 2026
    Article
  2. Review
  3. Article
  4. Review
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  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Biomedical applications of nanoflares: Targeted intracellular fluorescence probes.Nanomedicine : nanotechnology, biology, and medicine · 2019
    Review
  13. Identification of the Constituents of Percutaneous Absorption fromInternational journal of analytical chemistry · 2019
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Microfabricated Probes for Studying Brain Chemistry: A Review.Chemphyschem : a European journal of chemical physics and physical chemistry · 2018
    Review
  19. Article
  20. [Experimental factors affectingZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2018
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Rachel A SaylorDepartment of Chemistry, University of Kansas, Lawrence, KS 66045, USA; Ralph N. Adams Institute for Bioanalytical Chemistry, University of Kansas, Lawrence, KS 66047, USA. Electronic address: rsaylor@ku.edu.
Susan M LunteDepartment of Chemistry, University of Kansas, Lawrence, KS 66045, USA; Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS 66047, USA; Ralph N. Adams Institute for Bioanalytical Chemistry, University of Kansas, Lawrence, KS 66047, USA. Electronic address: slunte@ku.edu.

Funding

Analytical Methods for Investigating Peptide TransportR01NS042929 · NINDS · UNIVERSITY OF KANSAS LAWRENCE · PI LUNTE, SUSAN M · 2002 to 2011
$2.3M
NINDS NIH HHS R01 NS042929
6 · The paper itself

Abstract

Microdialysis is a powerful sampling technique that enables monitoring of dynamic processes in vitro and in vivo. The combination of microdialysis with chromatographic or electrophoretic methods with selective detection yields a "separation-based sensor" capable of monitoring multiple analytes in near real time. For monitoring biological events, analysis of microdialysis samples often requires techniques that are fast (<1 min), have low volume requirements (nL-pL), and, ideally, can be employed on-line. Microchip electrophoresis fulfills these requirements and also permits the possibility of integrating sample preparation and manipulation with detection strategies directly on-chip. Microdialysis coupled to microchip electrophoresis has been employed for monitoring biological events in vivo and in vitro. This review discusses technical considerations for coupling microdialysis sampling and microchip electrophoresis, including various interface designs, and current applications in the field.

Indexed as

Electrophoresis, MicrochipMicrodialysisAnimalsEnvironmental MonitoringHumansElectrochemical detectionElectrophoresisLab-on-a-chipMicrodialysisMicrofluidicsSensor

Identifiers

PMID25637011
PMCPMC4403801

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.