ArticleCerebral cortex (New York, N.Y. : 1991)2016
Unmasking Language Lateralization in Human Brain Intrinsic Activity.
Article in Cerebral cortex (New York, N.Y. : 1991), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Trial
- Molecular and cellular correlates of human cortical lateralization.Communications biology · 2026Article
- Brain function in language and associated networks in non- or minimally verbal children.Brain communications · 2026Article
- Dynamic brain lateralization patterns in Chinese naturalistic language comprehension and association with sex differences: a 7T functional magnetic resonance imaging study.Psychoradiology · 2026Article
- The molecular and cellular underpinnings of human brain lateralization.bioRxiv : the preprint server for biology · 2025Article
- Lateralization Disruption and Dynamic Balance Alterations in Alzheimer's Disease: Impacts on Hemispheric Interaction and Cognitive Performance.Human brain mapping · 2025Article
- Language Functional Connectivity Alterations During Resting State in Brain Arteriovenous Malformation Patients.CNS neuroscience & therapeutics · 2025Article
- Cortical language areas are coupled via a soft hierarchy of model-based linguistic features.bioRxiv : the preprint server for biology · 2025Article
- The lateralized cerebellum: insights into motor, cognitive, and affective functioning across ages: a scoping review.Journal of neurology · 2025Article
- Neuroplasticity and functional reorganization of language in patients with arteriovenous malformations: insights from neuroimaging and clinical interventions.Frontiers in human neuroscience · 2025Review
- Modulate the impact of the drowsiness on the resting state functional connectivity.Scientific reports · 2024Article
- 3D CNN for neuropsychiatry: Predicting Autism with interpretable Deep Learning applied to minimally preprocessed structural MRI data.PloS one · 2024Article
- The relationship between interhemispheric homotopic functional connectivity and left-right difference of intrahemispheric functional integration in the human brain.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- The unity and diversity of verbal and visuospatial creativity: Dynamic changes in hemispheric lateralisation.Human brain mapping · 2023Article
- Dynamic and stationary brain connectivity during movie watching as revealed by functional MRI.Brain structure & function · 2022Article
- Dynamic changes in brain lateralization correlate with human cognitive performance.PLoS biology · 2022Article
- Right-hemispheric language reorganization in patients with brain arteriovenous malformations: A functional magnetic resonance imaging study.Human brain mapping · 2021Article
- Large-scale functional brain networks for consciousness.Anatomy & cell biology · 2021Review
- Interhemispheric Parietal-Frontal Connectivity Predicts the Ability to Acquire a Nondominant Hand Skill.Brain connectivity · 2021Article
- The effect of global signal regression on DCM estimates of noise and effective connectivity from resting state fMRI.NeuroImage · 2020Article
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7 authors.
Funding
Abstract
Lateralization of function is a fundamental feature of the human brain as exemplified by the left hemisphere dominance of language. Despite the prominence of lateralization in the lesion, split-brain and task-based fMRI literature, surprisingly little asymmetry has been revealed in the increasingly popular functional imaging studies of spontaneous fluctuations in the fMRI BOLD signal (so-called resting-state fMRI). Here, we show the global signal, an often discarded component of the BOLD signal in resting-state studies, reveals a leftward asymmetry that maps onto regions preferential for semantic processing in left frontal and temporal cortex and the right cerebellum and a rightward asymmetry that maps onto putative attention-related regions in right frontal, temporoparietal, and parietal cortex. Hemispheric asymmetries in the global signal resulted from amplitude modulation of the spontaneous fluctuations. To confirm these findings obtained from normal, healthy, right-handed subjects in the resting-state, we had them perform 2 semantic processing tasks: synonym and numerical magnitude judgment and sentence comprehension. In addition to establishing a new technique for studying lateralization through functional imaging of the resting-state, our findings shed new light on the physiology of the global brain signal.
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