Evidence map›Paper›PMID 25636892›Full record

ArticleThe international journal of neuropsychopharmacology2015

Chronic Lithium Treatment Enhances the Number of Quiescent Neural Progenitors but Not the Number of DCX-Positive Immature Neurons.

N Kara, S Narayanan, R H Belmaker, H Einat, V A Vaidya, G Agam

Open access · goldAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in The international journal of neuropsychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

N KaraDepartment of Clinical Biochemistry and Pharmacology (Ms Kara and Dr Agam), and Psychiatry Research Unit (Ms Kara and Drs Belmaker and Agam), Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel; Mental Health Center, Beer-Sheva, Israel (Ms Kara and Dr Agam); Tel Aviv-Yaffo Academic College, Tel Aviv-Yaffo, Israel (Ms Kara and Dr Einat); Tata Institute of Fundamental Research, Mumbai, India (Ms Narayanan and Dr Vaidya); University of Minnesota, Minneapolis, Minnesota (Dr Einat).
S NarayananDepartment of Clinical Biochemistry and Pharmacology (Ms Kara and Dr Agam), and Psychiatry Research Unit (Ms Kara and Drs Belmaker and Agam), Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel; Mental Health Center, Beer-Sheva, Israel (Ms Kara and Dr Agam); Tel Aviv-Yaffo Academic College, Tel Aviv-Yaffo, Israel (Ms Kara and Dr Einat); Tata Institute of Fundamental Research, Mumbai, India (Ms Narayanan and Dr Vaidya); University of Minnesota, Minneapolis, Minnesota (Dr Einat).
R H BelmakerDepartment of Clinical Biochemistry and Pharmacology (Ms Kara and Dr Agam), and Psychiatry Research Unit (Ms Kara and Drs Belmaker and Agam), Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel; Mental Health Center, Beer-Sheva, Israel (Ms Kara and Dr Agam); Tel Aviv-Yaffo Academic College, Tel Aviv-Yaffo, Israel (Ms Kara and Dr Einat); Tata Institute of Fundamental Research, Mumbai, India (Ms Narayanan and Dr Vaidya); University of Minnesota, Minneapolis, Minnesota (Dr Einat).
H EinatDepartment of Clinical Biochemistry and Pharmacology (Ms Kara and Dr Agam), and Psychiatry Research Unit (Ms Kara and Drs Belmaker and Agam), Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel; Mental Health Center, Beer-Sheva, Israel (Ms Kara and Dr Agam); Tel Aviv-Yaffo Academic College, Tel Aviv-Yaffo, Israel (Ms Kara and Dr Einat); Tata Institute of Fundamental Research, Mumbai, India (Ms Narayanan and Dr Vaidya); University of Minnesota, Minneapolis, Minnesota (Dr Einat).
V A VaidyaDepartment of Clinical Biochemistry and Pharmacology (Ms Kara and Dr Agam), and Psychiatry Research Unit (Ms Kara and Drs Belmaker and Agam), Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel; Mental Health Center, Beer-Sheva, Israel (Ms Kara and Dr Agam); Tel Aviv-Yaffo Academic College, Tel Aviv-Yaffo, Israel (Ms Kara and Dr Einat); Tata Institute of Fundamental Research, Mumbai, India (Ms Narayanan and Dr Vaidya); University of Minnesota, Minneapolis, Minnesota (Dr Einat).
G AgamDepartment of Clinical Biochemistry and Pharmacology (Ms Kara and Dr Agam), and Psychiatry Research Unit (Ms Kara and Drs Belmaker and Agam), Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel; Mental Health Center, Beer-Sheva, Israel (Ms Kara and Dr Agam); Tel Aviv-Yaffo Academic College, Tel Aviv-Yaffo, Israel (Ms Kara and Dr Einat); Tata Institute of Fundamental Research, Mumbai, India (Ms Narayanan and Dr Vaidya); University of Minnesota, Minneapolis, Minnesota (Dr Einat). galila@bgu.ac.il vvaidya@tifr.res.in.
Academic College of Tel Aviv-Yafo · ILGeha Mental Health Center · ILBen-Gurion University of the Negev · ILTata Institute of Fundamental Research · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe term adult neurogenesis constitutes a series of developmental steps including the birth, survival, differentiation, maturation, and even death of newborn progenitor cells within neurogenic niches. Within the hippocampus progenitors reside in the neurogenic niche of the subgranular zone in the dentate gyrus subfield. At the different stages, designated type-I, type-IIa, type-IIb, type-III, and granule cell neurons, the cells express a series of markers enabling their identification and visualization. Lithium has been shown to increase hippocampal cell proliferation in the subgranular zone of the hippocampal dentate gyrus subfield of adult rodents and to stimulate the proliferation of hippocampal progenitor cells in vitro, but data regarding lithium's ability to increase neuronal differentiation and survival is equivocal.

methodsTo clarify the effect of lithium on adult hippocampal neurogenesis, we identified the effect of chronic lithium treatment on distinct stages of hippocampal progenitor development using adult Nestin-green fluorescent protein transgenic mice and immunofluorescent techniques.

resultsThe present observations confirm that lithium targets the initial stages of progenitor development enhancing the turnover of quiescent neural progenitors/putative stem-cells, corroborating previous reports. However, the enhanced quiescent neural progenitor-turnover does not translate into an increased number of immature neurons. We also observed a steep decline in the number of type-III immature neurons with complex tertiary-dendrites, suggesting that lithium alters the morphological maturation of newborn neurons.

conclusionsOur results do not corroborate previous reports of lithium-induced enhanced numbers of newly generated neurons.

Indexed as

Adult Stem CellsAnimalsCell DifferentiationCell ProliferationDentate GyrusDoublecortin ProteinGreen Fluorescent ProteinsHippocampusLithium CompoundsMaleMiceMice, TransgenicNestinNeural Stem CellsNeurogenesisNeuronsDcx protein, mouseDoublecortin ProteinGreen Fluorescent ProteinsLithium CompoundsNes protein, mouseNestinimmature neuronslithiumNestin-GFP transgenic miceneurogenesisquiescent neural progenitor cells

Identifiers

PMID25636892
PMCPMC4540105
OpenAlexW2163267563

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.