Evidence map›Paper›PMID 25636791›Full record

ArticleBMJ open2015

Methamphetamine and cannabis abuse in adolescence: a quasi-experimental study on specific and long-term neurocognitive effects.

Natalie L Cuzen, Sheri-Michelle Koopowitz, Helen L Ferrett, Dan J Stein, Deborah Yurgelun-Todd

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Natalie L CuzenDepartment of Psychiatry and Mental Health, University of Cape Town, Cape Town, Western Cape, South Africa.
Sheri-Michelle KoopowitzDepartment of Psychiatry and Mental Health, University of Cape Town, Cape Town, Western Cape, South Africa.
Helen L FerrettDepartment of Psychiatry, University of Stellenbosch, Cape Town, South Africa.
Dan J SteinDepartment of Psychiatry and Mental Health, University of Cape Town, Cape Town, Western Cape, South Africa.
Deborah Yurgelun-ToddBrain Institute, University of Utah School of Medicine, Salt Lake City, Utah, USA Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, Utah, USA.
University of Cape Town · ZAStellenbosch University · ZAUniversity of Utah · US

Funding

Brain Changes with Cannabis and MethamphetamineR21DA021422 · NIDA · UNIVERSITY OF UTAH · PI YURGELUN-TODD, DEBORAH A. · 2007 to 2008
$259k
NIDA NIH HHS R21 DA021422NIDA NIH HHS R21 DA021422-01
6 · The paper itself

Abstract

objectivesMethamphetamine abuse affects brain structure and function. Although methamphetamine and cannabis are commonly abused together, few studies have investigated the differential neurocognitive consequences of methamphetamine abuse with or without cannabis. Furthermore, the effects of drug use on the developing adolescent brain remain poorly understood. We compared neurocognitive function between adolescents with 'pure' methamphetamine abuse, those with comorbid methamphetamine and cannabis abuse, and healthy controls at baseline and follow-up.

methodsIndividuals residing in the greater Cape Town region, between the ages of 13 and 18 years, were recruited into either Methamphetamine only group (Meth-only; n=10), Methamphetamine and cannabis group (Meth-cann; n=10) or healthy control (n=20) groups using a quasi-experimental design. All participants underwent a comprehensive neurocognitive assessment. Substance-use variables and psychiatric symptom counts were also recorded. A portion of the Meth-only and control participants completed 12-month follow-up assessments.

resultsWhile the Meth-cann group demonstrated widespread neurocognitive deficits at baseline, these deficits were restricted to the self-monitoring domain in the Meth-only group at baseline and at follow-up.

conclusionsMethamphetamine abuse with cannabis abuse is associated with significantly more neurocognitive impairment than methamphetamine abuse alone, and such deficits may be enduring.

Indexed as

AdolescentAdolescent BehaviorAmphetamine-Related DisordersCognition DisordersComorbidityFemaleFollow-Up StudiesHumansMaleMarijuana AbuseNeuropsychological TestsSouth Africaadolescencecannabisexternalizingmethamphetamineneurocognition

Identifiers

PMID25636791
PMCPMC4316423
OpenAlexW2024873351

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.