Evidence map›Paper›PMID 25636743›Full record

ArticleEuropean heart journal2015

Sleep disordered breathing and post-discharge mortality in patients with acute heart failure.

Rami Khayat, David Jarjoura, Kyle Porter, Angela Sow, Jacob Wannemacher, Robert Dohar, Adam Pleister, William T Abraham

2 registry-linked trialsOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 113 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
113citing papers in PubMed, 4 pooled it
20.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04752462 nacompletednot on this mapstarted 2021, after this paper: background citation

Effect of Post-Discharge Telemedicine Motivational Enhancement Intervention in Heart Failure and Obstructive Sleep Apnea on Adherence and Health Outcomes

TypeinterventionalSponsorThe Cleveland ClinicRan2021 to 2025Enrolled75ConditionsAcute Decompensated Heart Failure, Obstructive Sleep Apnea, Motivational Enhancement, PAP AdherenceArmsTelemedicine Intensive Motivational Enhancement
NCT05913739 naterminatednot on this mapstarted 2022, after this paper: background citation

Impact of Oxygen Therapy on Readmissions of Patients With Chronic Heart Failure With Reduced Ejection Fraction

TypeinterventionalSponsorInstitut d'Investigació Biomèdica de Girona Dr. Josep TruetaRan2022 to 2024Enrolled1ConditionsChronic Heart Failure, Oxygen DeficiencyArmsOxygen Therapy
3 · Its place in the literature

Who cites it

113 citing papers in PubMed, 4 syntheses or guidelines pooled it, 266 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. The effect of obstructive sleep apnea on the increased risk of cardiovascular disease: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Pooled it
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  11. Automatic positive airway pressure for obstructive sleep apnea in heart failure with reduced ejection fraction.Clinical research in cardiology : official journal of the German Cardiac Society · 2021
    Trial
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  16. Article
  17. Oxygen overshoot burden of central sleep apnea and its association with cardiovascular outcomes.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026
    Article
  18. Review
  19. Review
  20. Review

53 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Rami KhayatSleep Heart Program, The Ohio State University, Columbus, OH, USA rami.khayat@osumc.edu.
David JarjouraCenter for Biostatistics, The Ohio State University, Columbus, OH, USA.
Kyle PorterCenter for Biostatistics, The Ohio State University, Columbus, OH, USA.
Angela SowSleep Heart Program, The Ohio State University, Columbus, OH, USA.
Jacob WannemacherSleep Heart Program, The Ohio State University, Columbus, OH, USA.
Robert DoharSleep Heart Program, The Ohio State University, Columbus, OH, USA.
Adam PleisterSleep Heart Program, The Ohio State University, Columbus, OH, USA Division of Cardiovascular Medicine, The Ohio State University, Columbus, OH, USA.
William T AbrahamSleep Heart Program, The Ohio State University, Columbus, OH, USA Division of Cardiovascular Medicine, The Ohio State University, Columbus, OH, USA.
The Ohio State University · US

Funding

The Ohio State University Center for clinical and Translational ScienceUL1TR001070 · NCATS · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA D · 2013 to 2017
$22.6M
TRAINING U54EB020404 · NIBIB · UNIVERSITY OF MEMPHIS · PI KUMAR, SANTOSH · 2014 to 2018
$11.3M
The Role of Obstructive Sleep Apnea in the Acutely Decompensated Heart FailureR21HL092480 · NHLBI · OHIO STATE UNIVERSITY · PI KHAYAT, RAMI N · 2008 to 2009
$413k
NCATS NIH HHS UL1 TR001070NHLBI NIH HHS R21 HL092480NIBIB NIH HHS U54 EB020404PHS HHS ULRR025755
6 · The paper itself

Abstract

backgroundHospitalizations for heart failure are associated with a high post-discharge risk for mortality. Identification of modifiable predictors of post-discharge mortality during hospitalization may improve outcome. Sleep disordered breathing (SDB) is the most common co-morbidity in heart failure patients. DESIGN, SETTING, AND

participantsProspective cohort study of patients hospitalized with acute heart failure (AHF) in a single academic heart hospital. Between January 2007 and December 2010, all patients hospitalized with AHF who have left ventricular ejection fraction (LVEF) ≤ 45% and were not already diagnosed with SDB were the target population. MAIN OUTCOMES AND MEASURES: Patients underwent in-hospital attended polygraphy testing for SDB and were followed for a median of 3 years post-discharge. Mortality was recorded using national and state vital statistics databases.

resultsDuring the study period, 1117 hospitalized AHF patients underwent successful sleep testing. Three hundred and forty-four patients (31%) had central sleep apnoea (CSA), 525(47%) patients had obstructive sleep apnoea (OSA), and 248 had no or minimal SDB (nmSDB). Of those, 1096 patients survived to discharge and were included in the mortality analysis. Central sleep apnoea was independently associated with mortality. The multivariable hazard ratio (HR) for time to death for CSA vs. nmSDB was 1.61 (95% CI: 1.1, 2.4, P = 0.02). Obstructive sleep apnoea was also independently associated with mortality with a multivariable HR vs. nmSDB of 1.53 (CI: 1.1, 2.2, P = 0.02). The Cox proportional hazards model adjusted for the following covariates: LVEF, age, BMI, sex, race, creatinine, diabetes, type of cardiomyopathy, coronary artery disease, chronic kidney disease, discharge systolic blood pressure <110, hypertension, discharge medications, initial length of stay, admission sodium, haemoglobin, and BUN.

conclusionsThis is the largest study to date to evaluate the effect of SDB on post-discharge mortality in patients with AHF. Newly diagnosed CSA and OSA during AHF hospitalization are independently associated with post-discharge mortality.

Indexed as

Acute DiseaseEpidemiologic MethodsFemaleHeart FailureHospitalizationHumansMaleMiddle AgedPrognosisSleep Apnea SyndromesStroke VolumeTreatment OutcomeHeart failurePost-discharge mortalitySleep apnoeaSleep disordered breathing

Identifiers

PMID25636743
PMCPMC4465635
OpenAlexW2110480388

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.