ReviewJournal of physiological anthropology2015
Natural environments, ancestral diets, and microbial ecology: is there a modern "paleo-deficit disorder"? Part I.
Review in Journal of physiological anthropology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 68 citations in OpenAlex.
- Unveiling the viral dimension: The paediatric gut virome as a key modulator of gastrointestinal metabolic, and neurodevelopmental health.World journal of virology · 2026Review
- Nutrition as a Cultural-Biological Regulator of Ageing: The Concept of Ethnonutrigerontology.Cureus · 2026Review
- Mechanism and implications of pro-nature physical activity in antagonizing psychological stress: the key role of microbial-gut-brain axis.Frontiers in psychology · 2023Review
- Population healthy lifestyle changes in Abha city during COVID-19 lockdown, Saudi Arabia.Journal of family medicine and primary care · 2021Article
- Virtual Reality Representations of Nature to Improve Well-Being amongst Older Adults: a Rapid Review.Journal of technology in behavioral science · 2021Review
- Spaceship Earth Revisited: The Co-Benefits of Overcoming Biological Extinction of Experience at the Level of Person, Place and Planet.International journal of environmental research and public health · 2020Article
- Harnessing the Four Elements for Mental Health.Frontiers in psychiatry · 2019Review
- The importance of the exposome and allostatic load in the planetary health paradigm.Journal of physiological anthropology · 2018Review
- Advanced Metrics for Assessing Holistic Care: The "Epidaurus 2" Project.Global advances in health and medicine · 2018Article
- Natural environments, nature relatedness and the ecological theater: connecting satellites and sequencing to shinrin-yoku.Journal of physiological anthropology · 2016Article
- Dysbiotic drift: mental health, environmental grey space, and microbiota.Journal of physiological anthropology · 2015Review
- Addressing "Nature-Deficit Disorder": A Mixed Methods Pilot Study of Young Adults Attending a Wilderness Camp.Evidence-based complementary and alternative medicine : eCAM · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Famed microbiologist René J. Dubos (1901-1982) was an early pioneer in the developmental origins of health and disease (DOHaD) construct. In the 1960s, he conducted groundbreaking experimental research concerning the ways in which early-life experience with nutrition, microbiota, stress, and other environmental variables could influence later-life health outcomes. He also wrote extensively on potential health consequences of a progressive loss of contact with natural environments (now referred to as green or blue space), arguing that Paleolithic experiences have created needs, particularly in the mental realm, that might not be met in the context of rapid global urbanization. He posited that humans would certainly adapt to modern urban landscapes and high technology, but there might be a toll to be paid in the form of higher psychological distress (symptoms of anxiety and depression) and diminished quality of life. In particular, there might be an erosion of humanness, exemplified by declines in altruism/empathy. Here in the first of a two-part review, we examine contemporary research related to natural environments and question to what extent Dubos might have been correct in some of his 50-year-old assertions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.