ArticleRadiation and environmental biophysics2015
Low-radiation environment affects the development of protection mechanisms in V79 cells.
Article in Radiation and environmental biophysics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 64 citations in OpenAlex.
- Low-dose X-ray radiation induces an adaptive response: A potential countermeasure to galactic cosmic radiation exposure.Experimental physiology · 2026Article
- Cosmic silence and viral noise: transcriptomic crosstalk inFrontiers in microbiology · 2026Article
- Low-Dose Non-Targeted Effects and Mitochondrial Control.International journal of molecular sciences · 2023Review
- Progress in biological and medical research in the deep underground: an update.Frontiers in public health · 2023Review
- Radiation dose rate effects: what is new and what is needed?Radiation and environmental biophysics · 2022Review
- Seedling Biometry ofPlants (Basel, Switzerland) · 2022Article
- Changes in Radiosensitivity to Gamma-Rays of Lymphocytes from Hyperthyroid Patients Treated with I-131.International journal of molecular sciences · 2022Article
- Transcriptome analysis of well-differentiated laryngeal squamous cell carcinoma cells in below-background environment.Annals of translational medicine · 2022Article
- Reduced Environmental Dose Rates Are Responsible for the Increased Susceptibility to Radiation-Induced DNA Damage in Larval Neuroblasts ofInternational journal of molecular sciences · 2022Article
- Chinese hamster V79 cells' dependence on background ionizing radiation for optimal growth.Radiation and environmental biophysics · 2022Article
- First transcriptome profiling of D. melanogaster after development in a deep underground low radiation background laboratory.PloS one · 2021Article
- Article
- Whole Transcriptome Analysis Revealed a Stress Response to Deep Underground Environment Conditions in Chinese Hamster V79 Lung Fibroblast Cells.Frontiers in genetics · 2021Article
- Proteomics provides insights into the inhibition of Chinese hamster V79 cell proliferation in the deep underground environment.Scientific reports · 2020Article
- Ionizing Radiation-Induced Epigenetic Modifications and Their Relevance to Radiation Protection.International journal of molecular sciences · 2020Review
- The Response of Living Organisms to Low Radiation Environment and Its Implications in Radiation Protection.Frontiers in public health · 2020Review
- Underground Radiobiology: A Perspective at Gran Sasso National Laboratory.Frontiers in public health · 2020Article
- Potassium Radioisotope 40 as Component of Mitochondria Physiology: Therapy Proposal for Mitochondrial Disfunction Diseases.Frontiers in public health · 2020Article
- Oxidative Stress From Exposure to the Underground Space Environment.Frontiers in public health · 2020Review
- Low Radiation Environment Switches the Overgrowth-Induced Cell Apoptosis Toward Autophagy.Frontiers in public health · 2020Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Very little is known about the influence of environmental radiation on living matter. In principle, important information can be acquired by analysing possible differences between parallel biological systems, one in a reference-radiation environment (RRE) and the other in a low-radiation environment (LRE). We took advantage of the unique opportunity represented by the cell culture facilities at the Gran Sasso National Laboratories of the Istituto Nazionale di Fisica Nucleare, where environment dose rate reduction factors in the underground (LRE), with respect to the external laboratory (RRE), are as follows: 10(3) for neutrons, 10(7) for directly ionizing cosmic rays and 10 for total γ-rays. Chinese hamster V79 cells were cultured for 10 months in both RRE and LRE. At the end of this period, all the cultures were kept in RRE for another 6 months. Changes in the activities of antioxidant enzymes (superoxide dismutase, SOD; catalase, CAT; glutathione peroxidase, GPX) and spontaneous mutation frequency at the hypoxanthine-guanine phosphoribosyl transferase (hprt) locus were investigated. The results obtained suggest that environmental radiation might act as a trigger of defence mechanisms in V79 cells, specifically those in reference conditions, showing a higher degree of defence against endogenous damage as compared to cells grown in a very low-radiation environment. Our findings corroborate the hypothesis that environmental radiation contributes to the development of defence mechanisms in today living organisms/systems.
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