ReviewJournal of physiology, Paris
Mistakes were made: neural mechanisms for the adaptive control of action initiation by the medial prefrontal cortex.
Review in Journal of physiology, Paris. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
- Behavioral Decoding Reveals Cortical Endocannabinoid Potentiation during ΔbioRxiv : the preprint server for biology · 2025Article
- The Role of Striatum in Controlling Waiting during Reactive and Self-Timed Behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Neurostimulation to Improve Cognitive Flexibility.Current opinion in behavioral sciences · 2025Article
- Anterior cingulate cortex lesions impair multiple facets of task engagement not mediated by dorsomedial striatum neuron firing.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Encoding of self-initiated actions in axon terminals of the mesocortical pathway.Neurophotonics · 2024Article
- Optogenetic Inhibition of Rat Anterior Cingulate Cortex Impairs the Ability to Initiate and Stay on Task.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Prefrontal control of superior colliculus modulates innate escape behavior following adversity.Nature communications · 2024Article
- Distinct circuits in anterior cingulate cortex encode safety assessment and mediate flexibility of fear reactions.Neuron · 2023Article
- Dynorphin / kappa-opioid receptor regulation of excitation-inhibition balance toggles afferent control of prefrontal cortical circuits in a pathway-specific manner.Molecular psychiatry · 2023Article
- Using lickometry to infer differential contributions of salience network regions during compulsion-like alcohol drinking.Addiction neuroscience · 2023Article
- Activity Subspaces in Medial Prefrontal Cortex Distinguish States of the World.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Altered regional homogeneity in patients with ovarian cancer treated with chemotherapy: a resting state fMRI study.Brain imaging and behavior · 2022Article
- New directions in modelling dysregulated reward seeking for food and drugs.Neuroscience and biobehavioral reviews · 2022Review
- Front and center: Maturational dysregulation of frontal lobe functional neuroanatomic connections in attention deficit hyperactivity disorder.Frontiers in neuroanatomy · 2022Article
- Neural signals implicated in the processing of appetitive and aversive events in social and non-social contexts.Frontiers in systems neuroscience · 2022Review
- Defining the interconnectivity of the medial prefrontal cortex and ventral midbrain.Frontiers in molecular neuroscience · 2022Review
- Dose-Dependent Regulation on Prefrontal Neuronal Working Memory by Dopamine DFrontiers in neuroscience · 2022Article
- Coherent theta activity in the medial and orbital frontal cortices encodes reward value.eLife · 2021Article
- D1 dopamine receptors intrinsic activity and functional selectivity affect working memory in prefrontal cortex.Molecular psychiatry · 2021Article
- Functional Contribution of the Medial Prefrontal Circuitry in Major Depressive Disorder and Stress-Induced Depressive-Like Behaviors.Frontiers in behavioral neuroscience · 2021Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Studies in rats, monkeys and humans have established that the medial prefrontal cortex is crucial for the ability to exert adaptive control over behavior. Here, we review studies on the role of the rat medial prefrontal cortex in adaptive control, with a focus on simple reaction time tasks that can be easily used across species and have clinical relevance. The performance of these tasks is associated with neural activity in the medial prefrontal cortex that reflects stimulus detection, action timing, and outcome monitoring. We describe rhythmic neural activity that occurs when animals initiate a temporally extended action. Such rhythmic activity is coterminous with major changes in population spike activity. Testing animals over a series of sessions with varying pre-stimulus intervals showed that the signals adapt to the current temporal demands of the task. Disruptions of rhythmic neural activity occur on error trials (premature responding) and lead to a persistent encoding of the error and a subsequent change in behavioral performance (i.e. post-error slowing). Analysis of simultaneously recorded spike activity suggests that the presence of strong theta rhythms is coterminous with altered network dynamics, and might serve as a mechanism for adaptive control. Computational modeling suggests that these signals may enable learning from errors. Together, our findings contribute to an emerging literature and provide a new perspective on the neuronal mechanisms for the adaptive control of action.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.