ArticleEnvironmental health perspectives2015
Arsenic exposure and prevalence of the varicella zoster virus in the United States: NHANES (2003-2004 and 2009-2010).
Article in Environmental health perspectives, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 27 citations in OpenAlex.
- Continuing the Conversation About Arsenic.Integrative medicine (Encinitas, Calif.) · 2024Article
- Time to Recognize and Address the Serious Arsenic Problem.Integrative medicine (Encinitas, Calif.) · 2024Article
- Rare Earth and Platinum Group Elements In Sub-Saharan Africa and Global Health: The Dark Side of the Burgeoning of Technology.Environmental health insights · 2024Review
- Update of the risk assessment of inorganic arsenic in food.EFSA journal. European Food Safety Authority · 2024Article
- The interplay between environmental exposures and COVID-19 risks in the health of children.Environmental health : a global access science source · 2021Article
- Evaluating the effects between metal mixtures and serum vaccine antibody concentrations in children: a prospective birth cohort study.Environmental health : a global access science source · 2020Article
- Exposure to low-dose arsenic in early life alters innate immune function in children.Journal of immunotoxicology · 2019Article
- Cross sectional association of arsenic and seroprevalence of hepatitis B infection in the United States (NHANES 2003-2014).Environmental research · 2018Article
- Elevated Arsenic Exposure Is Associated with an Increased Risk of Chronic Hepatitis B Virus Infection: NHANES (2003-2014) in U.S. Adults.Current medical science · 2018Article
- Trends in urinary arsenic among the U.S. population by drinking water source: Results from the National Health and Nutritional Examinations Survey 2003-2014.Environmental research · 2018Article
- Arsenic exposure and risk of nonalcoholic fatty liver disease (NAFLD) among U.S. adolescents and adults: an association modified by race/ethnicity, NHANES 2005-2014.Environmental health : a global access science source · 2018Article
- DNA methylation in cord blood as mediator of the association between prenatal arsenic exposure and gestational age.Epigenetics · 2018Article
- Arsenic and Obesity: A Comparison of Urine Dilution Adjustment Methods.Environmental health perspectives · 2017Article
- Arsenic and Immune Response to Infection During Pregnancy and Early Life.Current environmental health reports · 2017Review
- The Unintended Consequences of a Gluten-free Diet.Epidemiology (Cambridge, Mass.) · 2017Article
- Arsenic: The Underrecognized Common Disease-inducing Toxin.Integrative medicine (Encinitas, Calif.) · 2017Article
- Activating transcription factor 4 underlies the pathogenesis of arsenic trioxide-mediated impairment of macrophage innate immune functions.Toxicology and applied pharmacology · 2016Article
- Arsenic exposure and the seroprevalence of total hepatitis A antibodies in the US population: NHANES, 2003-2012.Epidemiology and infection · 2016Article
- Elevated blood lead and cadmium levels associated with chronic infections among non-smokers in a cross-sectional analysis of NHANES data.Environmental health : a global access science source · 2016Article
- Environmental gradients explain species richness and community composition of coastal breeding birds in the Baltic Sea.PloS one · 2015Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundArsenic is an immunotoxicant. Clinical reports observe the reactivation of varicella zoster virus (VZV) in people who have recovered from arsenic poisoning and in patients with acute promyelocytic leukemia that have been treated with arsenic trioxide.
objectiveWe evaluated the association between arsenic and the seroprevalence of VZV IgG antibody in a representative sample of the U.S.
methodsWe analyzed data from 3,348 participants of the National Health and Nutrition Examination Survey (NHANES) 2003-2004 and 2009-2010 pooled survey cycles. Participants were eligible if they were 6-49 years of age with information on both VZV IgG and urinary arsenic concentrations. We used two measures of total urinary arsenic (TUA): TUA1 was defined as the sum of arsenite, arsenate, monomethylarsonic acid, and dimethylarsinic acid, and TUA2 was defined as total urinary arsenic minus arsenobetaine and arsenocholine.
resultsThe overall weighted seronegative prevalence of VZV was 2.2% for the pooled NHANES sample. The geometric means of TUA1 and TUA2 were 6.57 μg/L and 5.64 μg/L, respectively. After adjusting for age, sex, race, income, creatinine, and survey cycle, odds ratios for a negative VZV IgG result in association with 1-unit increases in natural log-transformed (ln)-TUA1 and ln-TUA2 were 1.87 (95% CI: 1.03, 3.44) and 1.40 (95% CI: 1.0, 1.97), respectively.
conclusionsIn this cross-sectional analysis, urinary arsenic was inversely associated with VZV IgG seroprevalence in the U.S. POPULATION: This finding is in accordance with clinical observations of zoster virus reactivation from high doses of arsenic. Additional studies are needed to confirm the association and evaluate causal mechanisms.
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