ReviewCurrent opinion in microbiology2015
How do bacteria tune translation efficiency?
Review in Current opinion in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
49 citing papers in PubMed.
- Collided ribosomes are rescued by the endonuclease Rae1 andbioRxiv : the preprint server for biology · 2026Article
- Spatial and genetic constraints govern transcription-translation coupling and mRNA degradation in bacteria.Nature microbiology · 2026Article
- Stoichiometry-induced differential selection on codon optimization among ribosomal protein genes in bacterial species.Molecular biology and evolution · 2026Article
- Protein translation can fluidize bacterial cytoplasm.PNAS nexus · 2024Article
- Synthetic biology approach revealed enhancement in haeme oxygenase-1 gene expression by codon pair optimization while reduction by codon deoptimization.Annals of medicine and surgery (2012) · 2024Article
- Translational efficiency in gas-fermenting bacteria: Adding a new layer of regulation to gene expression in acetogens.iScience · 2023Review
- Selective RNA Processing and Stabilization are Multi-Layer and Stoichiometric Regulators of Gene Expression in Escherichia coli.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Optimization of ribosome utilization inPNAS nexus · 2023Article
- Principles of gene regulation quantitatively connect DNA to RNA and proteins in bacteria.Science (New York, N.Y.) · 2022Article
- Engineered multiple translation initiation sites: a novel tool to enhance protein production in Bacillus licheniformis and other industrially relevant bacteria.Nucleic acids research · 2022Article
- Global and gene-specific translational regulation in Escherichia coli across different conditions.PLoS computational biology · 2022Article
- Global 5'-UTR RNA structure regulates translation of a SERPINA1 mRNA.Nucleic acids research · 2022Article
- Protein degradation sets the fraction of active ribosomes at vanishing growth.PLoS computational biology · 2022Article
- Direct measurements of mRNA translation kinetics in living cells.Nature communications · 2022Article
- Ribosome profiling enhances understanding of mycobacterial translation.Frontiers in microbiology · 2022Review
- Quantitative Control for Stoichiometric Protein Synthesis.Annual review of microbiology · 2021Article
- Article
- Origin and evolution of nonulosonic acid synthases and their relationship with bacterial pathogenicity revealed by a large-scale phylogenetic analysis.Microbial genomics · 2021Article
- A snapshot of translation in Mycobacterium tuberculosis during exponential growth and nutrient starvation revealed by ribosome profiling.Cell reports · 2021Article
- Inferring efficiency of translation initiation and elongation from ribosome profiling.Nucleic acids research · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Bacterial proteins are translated with precisely determined rates to meet cellular demand. In contrast, efforts to express recombinant proteins in bacteria are often met with large unpredictability in their levels of translation. The disconnect between translation of natural and synthetic mRNA stems from the lack of understanding of the strategy used by bacteria to tune translation efficiency (TE). The development of array-based oligonucleotide synthesis and ribosome profiling provides new approaches to address this issue. Although the major determinant for TE is still unknown, these high-throughput studies point out a statistically significant but mild contribution from the mRNA secondary structure around the start codon. Here I summarize those findings and provide a theoretical framework for measuring TE.
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