ArticleThe Journal of clinical endocrinology and metabolism2015
Body mass index (BMI) trajectories in infancy differ by population ancestry and may presage disparities in early childhood obesity.
Article in The Journal of clinical endocrinology and metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Risk Factors in the First 1000 Days of Life Associated With Childhood Obesity: A Systematic Review and Risk Factor Quality Assessment.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Pooled it
- GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI.Science advances · 2019Pooled it
- Does the association between early life growth and later obesity differ by race/ethnicity or socioeconomic status? A systematic review.Annals of epidemiology · 2017Pooled it
- Early rapid weight gain among formula-fed infants: Impact of formula type and maternal feeding styles.Pediatric obesity · 2019Trial
- Exercise during pregnancy and infant body mass index during the first year of life: a secondary per-protocol analysis of a randomized clinical trial.Frontiers in global women's health · 2026Article
- Timing based clustering of childhood BMI trajectories reveals differential maturational patterns; Study in the Northern Finland Birth Cohorts 1966 and 1986.International journal of obesity (2005) · 2025Article
- Prospective prediction of childhood body mass index trajectories using multi-task Gaussian processes.International journal of obesity (2005) · 2025Article
- Modelling individual infancy growth trajectories to predict excessive gain in BMI z-score: a comparison of growth measures in the ABCD and GECKO Drenthe cohorts.BMC public health · 2023Article
- Article
- Body Mass Index Growth Curves for Birth to 24 Months Children in Ankara with RefCurv SoftwareBalkan medical journal · 2023Article
- Endocrine Health and Health Care Disparities in the Pediatric and Sexual and Gender Minority Populations: An Endocrine Society Scientific Statement.The Journal of clinical endocrinology and metabolism · 2023Article
- Genetically-predicted placental gene expression is associated with birthweight and adult body mass index.Scientific reports · 2023Article
- Prevalence of early childhood obesity in Ireland: Differences over time, between sexes and across child growth criteria.Pediatric obesity · 2022Article
- Early childhood body mass index trajectory and overweight/obesity risk differed by maternal weight status.European journal of clinical nutrition · 2022Article
- Article
- Metabolite Profiles of the Relationship between Body Mass Index (BMI) Milestones and Metabolic Risk during Early Adolescence.Metabolites · 2020Article
- [Heritability of obesity in children aged 30-36 months and an analysis of single nucleotide polymorphisms at four loci in Xi'an, China].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2020Article
- Association of maternal prepregnancy weight and early childhood weight with obesity in adolescence: A population-based longitudinal cohort study in Japan.Pediatric obesity · 2020Article
- Risk Factors for Childhood Overweight and Obesity in Ukraine and GermanyJournal of clinical research in pediatric endocrinology · 2019Article
- [Influence of pre-pregnancy parental body mass index, maternal weight gain during pregnancy, and their interaction on neonatal birth weight].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2019Article
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Authors and funding
11 authors.
Funding
Abstract
contextNo consensus definition exists for excess adiposity during infancy. After age 2 years, high body mass index (BMI) is related to adverse cardiometabolic outcomes. Before age 2 years, the utility of BMI as a metric of excess adiposity is unknown.
objectivesThe objective of the study was to characterize infant BMI trajectories in a diverse, longitudinal cohort and investigate the relationship between the infancy BMI trajectory and childhood obesity. SUBJECTS: Healthy, nonpreterm infants (n = 2114) in the Genetic Causes for Complex Pediatric Disorders study (The Children's Hospital of Philadelphia) with six or more BMI measurements in the first 13.5 months participated in the study.
designFor each infant, the BMI trajectory was modeled using polynomial regression. Independent effects of clinical factors on magnitude and timing of peak BMI were assessed. The relationship between infancy BMI and early childhood BMI (age 4 y) was examined (n = 1075).
resultsThe cohort was 53% male and 61% African-American. Peak BMI was 18.6 ± 1.7 kg/m(2) and occurred at 8.6 ± 1.4 months. In multivariate analysis, boys had a higher (0.50 kg/m(2), P < .001) peak BMI than girls. The peak was higher (0.53 kg/m(2), P ≤ .001) and occurred earlier (by 12 d, P < .001) in African-American vs white children. The odds of obesity at age 4 years increased among children with higher (odds ratio 2.02; P < .001) and later (odds ratio 1.26; P = .02) infancy peak BMI.
conclusionsWe demonstrate sex- and ancestry-specific differences in infancy BMI and an association of infancy peak BMI with childhood BMI. These findings support the potential utility of infancy BMI to identify children younger than age 2 years with increased risk for later obesity.
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