Evidence map›Paper›PMID 25635890›Full record

ArticleNeurosurgery2015

Sacroplasty for cancer-associated insufficiency fractures.

Nelson Moussazadeh, Ilya Laufer, Timothy Werner, George Krol, Patrick Boland, Mark H Bilsky, Eric Lis

Open access · greenAbstract readCase Reports
In one paragraph

Article in Neurosurgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.

  1. Clinical outcomes of sacroplasty for metastatic sacral tumours: a systematic review and meta-analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2020
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  13. What's new in vertebral cementoplasty?The British journal of radiology · 2016
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  15. Short-segment percutaneous pedicle screw fixation with cement augmentation for tumor-induced spinal instability.The spine journal : official journal of the North American Spine Society · 2015
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Nelson Moussazadeh*Division of Neurological Surgery, Memorial Sloan Kettering Cancer Center, New York, New York; ‡Department of Neurological Surgery, Weill Cornell Medical College, New York-Presbyterian Hospital, New York, New York; §Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York; ¶Division of Orthopedic Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Ilya Laufer
Timothy Werner
George Krol
Patrick Boland
Mark H Bilsky
Eric Lis
Memorial Sloan Kettering Cancer Center · USCornell University · USNeurological Surgery · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

backgroundTumor-associated sacral insufficiency fractures (SIF) present a significant clinical challenge. As survival increases for many malignancies, sacral fractures associated with metastases, sacral or extended pelvic radiation, and paraneoplastic osteoporosis are increasingly common and yet remain difficult to treat in the setting of the potentially significant morbidity of open sacral surgery.

objectiveTo describe our prospective experience with sacroplasty for tumor-associated lesions, including the largest series to date of radiation-induced SIF.

methodsTwenty-five patients with symptomatic SIF underwent 31 percutaneous fluoroscopy-guided sacroplasties with a median 5.8 mL of polymethyl methacrylate or a ceramic-resin composite under fluoroscopic guidance and with concurrent biopsy acquisition. Eighteen patients had fractures related to previous sacral or pelvic radiation; 4 had viable lytic lesions; and 2 had oncology-related osteoporosis. Postoperative pain reduction, procedural morbidity, and functional outcomes were recorded.

resultsTwenty of 25 patients (80%) had reduction in their visual analog pain score at a median follow-up of 6.5 months; no patients worsened. The mean visual analog scale score decreased from 8.8 to 4.7 postprocedurally (P < .001), with significant reductions regardless of the underlying pathology (P < .001 to P < .05). Six of 13 patients with pretreatment ambulatory impairment required fewer ambulatory aids and 3 were newly ambulatory. Extravertebral cement migration was noted in 18 procedures; however, no instance was clinically relevant. Six repeat or contralateral procedures were performed. No morbidity was encountered.

conclusionSacroplasty is a safe and effective option for the palliation of sacral fractures in the oncologic population.

Indexed as

AdultAgedAged, 80 and overBone CementsFemaleFluoroscopyFractures, StressHumansMaleMiddle AgedNeoplasmsPain MeasurementPolymethyl MethacrylateRetrospective StudiesSacrumSpinal FracturesBone CementsPolymethyl Methacrylate

Identifiers

PMID25635890
PMCPMC12001087
OpenAlexW1981880148

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.