ArticlePLoS neglected tropical diseases2015
Classification of Bartonella strains associated with straw-colored fruit bats (Eidolon helvum) across Africa using a multi-locus sequence typing platform.
Article in PLoS neglected tropical diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 35 citations in OpenAlex.
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- Detection of bacterial and protozoan pathogens in individual bats and their ectoparasites using high-throughput microfluidic real-time PCR.Microbiology spectrum · 2023Article
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- Analysis of COI gene, prevalence, and intensity of the bat flyInternational journal for parasitology. Parasites and wildlife · 2023Article
- Molecular Detection and Phylogenetic Analyses of DiversePathogens (Basel, Switzerland) · 2022Article
- Bats and their ectoparasites (Nycteribiidae and Spinturnicidae) carry diverse novel Bartonella genotypes, China.Transboundary and emerging diseases · 2022Article
- Isolation ofPathogens (Basel, Switzerland) · 2020Article
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- Human Exposure to Novel Bartonella Species from Contact with Fruit Bats.Emerging infectious diseases · 2018Article
- Eco-epidemiology of Novel Bartonella Genotypes from Parasitic Flies of Insectivorous Bats.Microbial ecology · 2018Article
- Genetic diversity, infection prevalence, and possible transmission routes of Bartonella spp. in vampire bats.PLoS neglected tropical diseases · 2018Article
- Bartonella DNA in heart tissues of bats in central and eastern Europe and a review of phylogenetic relations of bat-associated bartonellae.Parasites & vectors · 2018Review
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- Prevalence, diversity, and host associations of Bartonella strains in bats from Georgia (Caucasus).PLoS neglected tropical diseases · 2017Article
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- Phylogenetic and geographic patterns of bartonella host shifts among bat species.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2016Article
- Bat trait, genetic and pathogen data from large-scale investigations of African fruit bats, Eidolon helvum.Scientific data · 2016Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bartonellae are facultative intracellular bacteria and are highly adapted to their mammalian host cell niches. Straw-colored fruit bats (Eidolon helvum) are commonly infected with several bartonella strains. To elucidate the genetic diversity of these bartonella strains, we analyzed 79 bartonella isolates from straw-colored fruit bats in seven countries across Africa (Cameroon, Annobon island of Equatorial Guinea, Ghana, Kenya, Nigeria, Tanzania, and Uganda) using a multi-locus sequencing typing (MLST) approach based on nucleotide sequences of eight loci (ftsZ, gltA, nuoG, ribC, rpoB, ssrA, ITS, and 16S rRNA). The analysis of each locus but ribC demonstrated clustering of the isolates into six genogroups (E1 - E5 and Ew), while ribC was absent in the isolates belonging to the genogroup Ew. In general, grouping of all isolates by each locus was mutually supportive; however, nuoG, gltA, and rpoB showed some incongruity with other loci in several strains, suggesting a possibility of recombination events, which were confirmed by network analyses and recombination/mutation rate ratio (r/m) estimations. The MLST scheme revealed 45 unique sequence types (ST1 - 45) among the analyzed bartonella isolates. Phylogenetic analysis of concatenated sequences supported the discrimination of six phylogenetic lineages (E1 - E5 and Ew) corresponding to separate and unique Bartonella species. One of the defined lineages, Ew, consisted of only two STs (ST1 and ST2), and comprised more than one-quarter of the analyzed isolates, while other lineages contained higher numbers of STs with a smaller number of isolates belonging to each lineage. The low number of allelic polymorphisms of isolates belonging to Ew suggests a more recent origin for this species. Our findings suggest that at least six Bartonella species are associated with straw-colored fruit bats, and that distinct STs can be found across the distribution of this bat species, including in populations of bats which are genetically distinct.
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