ArticlePloS one2015
Strain-level diversity of secondary metabolism in Streptomyces albus.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 1 of them a synthesis that pooled it.
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Who cites it
62 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- De-novo assembly of 82 bacterial genomes using Nanopore sequencing and prediction of biosynthetic capacity.Scientific data · 2026Article
- Genomic insights and biosynthetic gene cluster analysis ofMicrobiology spectrum · 2026Article
- A platform for CRISPRi-seq inmBio · 2026Article
- Eco-evolutionary dynamics sustain a potent yet rare antibiotic gene cluster in Streptomyces.The ISME journal · 2026Article
- A novel Streptomyces zaomyceticus metabolite exhibits antifungal activity against Candida albicans in African catfish.BMC veterinary research · 2026Article
- Bioassay-Guided Purification of Cytotoxic Isoflavonoids and Sesquiterpenoids ofIranian journal of biotechnology · 2025Article
- Beyond traditional screening: Unveiling antibiotic potentials of actinomycetes in extreme environments.Heliyon · 2024Article
- Morphological diversity of actinobacteria isolated from oil palm compost (Elaeis guineensis).Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Unveiling metabolo-genomic insights of potent antitumoral and antibiotic activity inFrontiers in microbiology · 2024Article
- A panoramic view of the genomic landscape of the genusMicrobial genomics · 2023Article
- Draft genome sequence of3 Biotech · 2023Article
- Whole genomes of deep-sea sponge-associated bacteria exhibit high novel natural product potential.FEMS microbes · 2023Article
- Expanding the genomic encyclopedia ofCell genomics · 2022Article
- Unveiling the genomic potential ofMicrobial genomics · 2022Article
- Great diversity of KSFEMS microbes · 2022Article
- Re-classification ofiScience · 2021Article
- Evolutionary genomics and biosynthetic potential of novel environmental Actinobacteria.Applied microbiology and biotechnology · 2021Article
- Article
- Phylogenomics, CAZyome and core secondary metabolome of Streptomyces albus species.Molecular genetics and genomics : MGG · 2021Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Streptomyces spp. are robust producers of medicinally-, industrially- and agriculturally-important small molecules. Increased resistance to antibacterial agents and the lack of new antibiotics in the pipeline have led to a renaissance in natural product discovery. This endeavor has benefited from inexpensive high quality DNA sequencing technology, which has generated more than 140 genome sequences for taxonomic type strains and environmental Streptomyces spp. isolates. Many of the sequenced streptomycetes belong to the same species. For instance, Streptomyces albus has been isolated from diverse environmental niches and seven strains have been sequenced, consequently this species has been sequenced more than any other streptomycete, allowing valuable analyses of strain-level diversity in secondary metabolism. Bioinformatics analyses identified a total of 48 unique biosynthetic gene clusters harboured by Streptomyces albus strains. Eighteen of these gene clusters specify the core secondary metabolome of the species. Fourteen of the gene clusters are contained by one or more strain and are considered auxiliary, while 16 of the gene clusters encode the production of putative strain-specific secondary metabolites. Analysis of Streptomyces albus strains suggests that each strain of a Streptomyces species likely harbours at least one strain-specific biosynthetic gene cluster. Importantly, this implies that deep sequencing of a species will not exhaust gene cluster diversity and will continue to yield novelty.
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