Evidence map›Paper›PMID 25635720›Full record

ArticleKidney international2015

If you lose your nerves, at least you will not get kidney fibrosis!

Peter Boor, Marios E Papasotiriou

Abstract readComment
PubMed Publisher
In one paragraph

Article in Kidney international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Peter Boor1] Institute of Pathology and Department of Nephrology, RWTH University of Aachen, Aachen, Germany [2] Institute of Molecular Biomedicine, Comenius University, Bratislava, Slovakia.
Marios E Papasotiriou1] Institute of Pathology and Department of Nephrology, RWTH University of Aachen, Aachen, Germany [2] Department of Nephrology, University of Patras, Patras, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Kidney fibrosis is one of the most promising treatment targets in nephrology. To design effective treatment approaches, a detailed understanding of the initiating mechanisms is of great importance. Kim and Pandanilam now find that renal nerves are a major trigger for renal fibrosis. Both afferent and efferent nerve fibers are involved via norepinephrine and α2-adrenergic receptors as well as calcitonin gene-related peptide (CGRP) and its receptors.

Indexed as

DenervationAnimalsKidneyMaleReperfusion Injury

Identifiers

PMID25635720

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.