ArticlePloS one2015
A G-protein β subunit, AGB1, negatively regulates the ABA response and drought tolerance by down-regulating AtMPK6-related pathway in Arabidopsis.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38 citing papers in PubMed, 72 citations in OpenAlex.
- Arabidopsis Heterotrimeric G Beta Variants Shape Plant Development and Modulate Responses to Endoplasmic Reticulum Stress and Salt Stress.Plant, cell & environment · 2026Article
- Plant G proteins: Versatile signaling hubs for synergistic improvement of agronomic traits.Journal of integrative plant biology · 2026Review
- The heterotrimeric G protein γ3 subunit, RGG3/GS3, integrates sugar-starvation and hormone-responsive signaling pathways to promote coleoptile elongation during anaerobic germination in rice.Plant molecular biology · 2025Article
- Molecular mechanism ofHorticulture research · 2025Article
- Plant PAQR-like sensors activate heterotrimeric G proteins to confer resistance against multiple pathogens.Molecular plant · 2025Article
- Proteomics revealed novel functions and drought tolerance of Arabidopsis thaliana protein kinase ATG1.BMC biology · 2025Article
- Genome-wide identification of heterotrimeric G protein genes in castor (Ricinus communis L.) and expression patterns under salt stress.BMC genomics · 2024Article
- Arabidopsis AGB1 participates in salinity response through bZIP17-mediated unfolded protein response.BMC plant biology · 2024Article
- OsAAI1 Increases Rice Yield and Drought Tolerance Dependent on ABA-Mediated Regulatory and ROS Scavenging Pathway.Rice (New York, N.Y.) · 2023Article
- Heterotrimeric G Protein-Mediated Signaling Is Involved in Stress-Mediated Growth Inhibition inInternational journal of molecular sciences · 2023Article
- Vitamin DCell biology and toxicology · 2023Article
- Molecular and biochemical characterization of rice developed through conventional integration of nDart1-0 transposon gene.Scientific reports · 2023Article
- The interplay of GTP-binding protein AGB1 with ER stress sensors IRE1a and IRE1b modulates Arabidopsis unfolded protein response and bacterial immunity.Plant signaling & behavior · 2022Article
- EXTRA LARGE G-PROTEIN2 mediates cell death and hyperimmunity in the chitin elicitor receptor kinase 1-4 mutant.Plant physiology · 2022Article
- FvWRKY48 binds to the pectate lyase FvPLA promoter to control fruit softening in Fragaria vesca.Plant physiology · 2022Article
- Heterotrimeric G Protein Signaling in Abiotic Stress.Plants (Basel, Switzerland) · 2022Review
- Biological Parts for Engineering Abiotic Stress Tolerance in Plants.Biodesign research · 2022Review
- Study on exogenous application of thidiazuron on seed size ofFrontiers in plant science · 2022Article
- Transcriptome-Wide Identification and Characterization of theInternational journal of molecular sciences · 2021Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heterotrimeric G-proteins are versatile regulators involved in diverse cellular processes in eukaryotes. In plants, the function of G-proteins is primarily associated with ABA signaling. However, the downstream effectors and the molecular mechanisms in the ABA pathway remain largely unknown. In this study, an AGB1 mutant (agb1-2) was found to show enhanced drought tolerance, indicating that AGB1 might negatively regulate drought tolerance in Arabidopsis. Data showed that AGB1 interacted with protein kinase AtMPK6 that was previously shown to phosphorylate AtVIP1, a transcription factor responding to ABA signaling. Our study found that transcript levels of three ABA responsive genes, AtMPK6, AtVIP1 and AtMYB44 (downstream gene of AtVIP1), were significantly up-regulated in agb1-2 lines after ABA or drought treatments. Other ABA-responsive and drought-inducible genes, such as RD29A (downstream gene of AtMYB44), were also up-regulated in agb1-2 lines. Furthermore, overexpression of AtVIP1 resulted in hypersensitivity to ABA at seed germination and seedling stages, and significantly enhanced drought tolerance in transgenic plants. These results suggest that AGB1 was involved in the ABA signaling pathway and drought tolerance in Arabidopsis through down-regulating the AtMPK6, AtVIP1 and AtMYB44 cascade.
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