ArticleThe ISME journal2015
A dynamic periplasmic electron transfer network enables respiratory flexibility beyond a thermodynamic regulatory regime.
Article in The ISME journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed, 153 citations in OpenAlex.
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- Identification of factors limiting the efficiency of transplanting extracellular electron transfer chains inApplied and environmental microbiology · 2025Article
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- Periplasmic Protein Mobility for Extracellular Electron Transport inMicroorganisms · 2025Article
- Decoupled respiration in electro-active bacteria.Communications biology · 2025Article
- Overlap and differences between the inward and outward electron transfer pathways in Shewanella oneidensis.FEMS microbiology letters · 2025Article
- Shewanella oneidensis: Biotechnological Application of Metal-Reducing Bacteria.Advances in biochemical engineering/biotechnology · 2025Review
- Novel Insights on Extracellular Electron Transfer Networks in theMicroorganisms · 2024Article
- Isolation and genomic analysis of "Applied and environmental microbiology · 2024Article
- Periplasmic electron transfer network in Geobacter sulfurreducens revealed by biomolecular interaction studies.Protein science : a publication of the Protein Society · 2024Article
- Widespread extracellular electron transfer pathways for charging microbial cytochrome OmcS nanowires via periplasmic cytochromes PpcABCDE.Nature communications · 2024Article
2 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microorganisms show an astonishing versatility in energy metabolism. They can use a variety of different catabolic electron acceptors, but they use them according to a thermodynamic hierarchy, which is determined by the redox potential of the available electron acceptors. This hierarchy is reflected by a regulatory machinery that leads to the production of respiratory chains in dependence of the availability of the corresponding electron acceptors. In this study, we showed that the γ-proteobacterium Shewanella oneidensis produces several functional electron transfer chains simultaneously. Furthermore, these chains are interconnected, most likely with the aid of c-type cytochromes. The cytochrome pool of a single S. oneidensis cell consists of ca. 700 000 hemes, which are reduced in the absence on an electron acceptor, but can be reoxidized in the presence of a variety of electron acceptors, irrespective of prior growth conditions. The small tetraheme cytochrome (STC) and the soluble heme and flavin containing fumarate reductase FccA have overlapping activity and appear to be important for this electron transfer network. Double deletion mutants showed either delayed growth or no growth with ferric iron, nitrate, dimethyl sulfoxide or fumarate as electron acceptor. We propose that an electron transfer machinery that is produced irrespective of a thermodynamic hierarchy not only enables the organism to quickly release catabolic electrons to a variety of environmental electron acceptors, but also offers a fitness benefit in redox-stratified environments.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.