ArticleJournal of neurosurgery2015
Frontal operculum gliomas: language outcome following resection.
Article in Journal of neurosurgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- A contemporary framework of language processing in the human brain in the context of preoperative and intraoperative language mapping.Neuroradiology · 2017Pooled it
- Intraoperative functional brain mapping for glioma surgery: a comprehensive review of the University of California San Francisco mapping protocol.Journal of neuro-oncology · 2026Review
- The Case for Neurosurgical Intervention in Cancer Neuroscience.Neurosurgery · 2025Review
- Involvement of the anterior insula and frontal operculum during wh-question comprehension of wh-in-situ Korean language.PloS one · 2024Article
- Evaluating syntactic comprehension during awake intraoperative cortical stimulation mapping.Journal of neurosurgery · 2023Article
- Spatiotemporally distributed frontotemporal networks for sentence reading.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- A review on surgical treatment options in gliomas.Frontiers in oncology · 2023Review
- A Neurosurgical Functional Dissection of the Middle Precentral Gyrus during Speech Production.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Review
- Review
- Anatomical aspects of the insula, opercula and peri-insular white matter for a transcortical approach to insular glioma resection.Neurosurgical review · 2022Article
- Brain connectomics applied to oncological neuroscience: from a traditional surgical strategy focusing on glioma topography to a meta-network approach.Acta neurochirurgica · 2021Review
- Superficial anatomy of the neonatal cerebrum - an ultrasonographic roadmap.Pediatric radiology · 2021Review
- Impact of connectivity between the pars triangularis and orbitalis on identifying the frontal language area in patients with dominant frontal gliomas.Neurosurgical review · 2020Article
- Selective Interference with Syntactic Encoding during Sentence Production by Direct Electrocortical Stimulation of the Inferior Frontal Gyrus.Journal of cognitive neuroscience · 2018Article
- Surgical oncology for gliomas: the state of the art.Nature reviews. Clinical oncology · 2018Review
- Article
- The transsylvian approach for resection of insular gliomas: technical nuances of splitting the Sylvian fissure.Journal of neuro-oncology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectThe dominant hemisphere frontal operculum may contain critical speech and language pathways, and due to these properties, patients with tumors of the opercular region may be at higher risk for postoperative speech dysfunction. However, the likelihood of incurring temporary or permanent language dysfunction is unknown.
methodsThe authors retrospectively analyzed their cohort of patients with frontal gliomas to identify those tumors that predominantly involved the dominant frontal operculum. Each tumor was classified as involving the pars orbitalis, pars triangularis, pars opercularis, or a combination of some or all of these areas. The authors then identified and compared characteristics between those patients experiencing transient or permanent speech deficits, as opposed to those with no language dysfunction.
resultsForty-three patients were identified for inclusion in this analysis. Transient deficits occurred in 12 patients (27.9%), while 4 patients (9.8%) had persistent deficits involving language. Individuals with preoperative language deficits and patients with seizures characterized by speech dysfunction appear to be at the highest risk to develop a deficit (relative risks 3.09 and 1.75, respectively). No patient with a tumor involving the pars orbitalis experienced a persistent deficit.
conclusionsResection of gliomas is widely recognized as a critical element of improved outcome. Given the low rate of language morbidity reported in this group of patients, resection of gliomas within the dominant frontal operculum is well-tolerated with acceptable morbidity and, in this particular location, should not be a deterrent in the overall management of these tumors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.