ArticleSpringerPlus2015
Wake-active neurons across aging and neurodegeneration: a potential role for sleep disturbances in promoting disease.
Article in SpringerPlus, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 44 citations in OpenAlex.
- Impaired 24-h activity patterns are associated with an increased risk of Alzheimer's disease, Parkinson's disease, and cognitive decline.Alzheimer's research & therapy · 2024Article
- Proteostasis failure exacerbates neuronal circuit dysfunction and sleep impairments in Alzheimer's disease.Molecular neurodegeneration · 2023Review
- RCAN1 knockout and overexpression recapitulate an ensemble of rest-activity and circadian disruptions characteristic of Down syndrome, Alzheimer's disease, and normative aging.Journal of neurodevelopmental disorders · 2022Article
- Tau and β-Amyloid Burden Predict Actigraphy-Measured and Self-Reported Impairment and Misperception of Human Sleep.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Widespread Reduced Density of Noradrenergic Locus Coeruleus Axons in the App Knock-In Mouse Model of Amyloid-β Amyloidosis.Journal of Alzheimer's disease : JAD · 2021Article
- Profound degeneration of wake-promoting neurons in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2019Article
- Sleep and Attention in Alzheimer's Disease.The Yale journal of biology and medicine · 2019Review
- The influence of non-breathing-related sleep fragmentation on cognitive function in patients with cerebral small vessel disease.Neuropsychiatric disease and treatment · 2019Article
- Potential for the development of light therapies in mild traumatic brain injury.Concussion (London, England) · 2018Review
- Selective Vulnerability of Brainstem Nuclei in Distinct Tauopathies: A Postmortem Study.Journal of neuropathology and experimental neurology · 2018Article
- Promotion of the Unfolding Protein Response in Orexin/Dynorphin Neurons in Sudden Infant Death Syndrome (SIDS): Elevated pPERK and ATF4 Expression.Molecular neurobiology · 2017Article
- Exploring the nap paradox: are mid-day sleep bouts a friend or foe?Sleep medicine · 2017Review
- Sleep and Human Aging.Neuron · 2017Review
- Altered sleep and EEG power in the P301S Tau transgenic mouse model.Annals of clinical and translational neurology · 2017Article
- Sleep in Alzheimer's Disease - Beyond Amyloid.Neurobiology of sleep and circadian rhythms · 2017Article
- Circadian Rhythms, Sleep, and Disorders of Aging.Trends in endocrinology and metabolism: TEM · 2016Review
- Ageing delays emergence from general anaesthesia in rats by increasing anaesthetic sensitivity in the brain.British journal of anaesthesia · 2015Article
- Sleep-Wake Cycle Dysfunction in the TgCRND8 Mouse Model of Alzheimer's Disease: From Early to Advanced Pathological Stages.PloS one · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Sleep/wake disturbance is a feature of almost all common age-related neurodegenerative diseases. Although the reason for this is unknown, it is likely that this inability to maintain sleep and wake states is in large part due to declines in the number and function of wake-active neurons, populations of cells that fire only during waking and are silent during sleep. Consistent with this, many of the brain regions that are most susceptible to neurodegeneration are those that are necessary for wake maintenance and alertness. In the present review, these wake-active populations are systematically assessed in terms of their observed pathology across aging and several neurodegenerative diseases, with implications for future research relating sleep and wake disturbances to aging and age-related neurodegeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.