Evidence map›Paper›PMID 25635112›Full record

ArticlePlant physiology2015

Perturbation of maize phenylpropanoid metabolism by an AvrE family type III effector from Pantoea stewartii.

Jo Ann E Asselin, Jinshan Lin, Alvaro L Perez-Quintero, Irene Gentzel, Doris Majerczak, Stephen O Opiyo, Wanying Zhao, Seung-Mann Paek, Min Gab Kim, David L Coplin and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plant physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
10.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 51 citations in OpenAlex.

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  3. The role ofApplied and environmental microbiology · 2025
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  5. Extracellular niche establishment by plant pathogens.Nature reviews. Microbiology · 2024
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  11. Review
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  15. Novel Effector RHIFs Identified FromFrontiers in plant science · 2021
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  16. The Transcription Factor Lrp ofFrontiers in microbiology · 2021
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  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Jo Ann E AsselinDepartment of Horticulture and Crop Science (J.E.A., J.L., A.L.P.-Q., Do.M., W.Z., J.J.B., Da.M.), Molecular and Cellular Imaging Center-Columbus, Ohio Agricultural Research and Development Center (J.L., S.O.O., J.J.B.), Translational Plant Sciences Graduate Program (I.G.), Center for Applied Plant Sciences (I.G., Da.M.), Department of Plant Pathology (D.L.C.), and Department of Molecular Genetics (Da.M.), Ohio State University, Columbus, Ohio 43210; andCollege of Pharmacy, Research Institute of Pharmaceutical Science, Plant Molecular Biology and Biotechnology Research Center, Gyeongsang National University, Jinju 660-751, Republic of Korea (S.-M.P., M.G.K.).
Jinshan LinDepartment of Horticulture and Crop Science (J.E.A., J.L., A.L.P.-Q., Do.M., W.Z., J.J.B., Da.M.), Molecular and Cellular Imaging Center-Columbus, Ohio Agricultural Research and Development Center (J.L., S.O.O., J.J.B.), Translational Plant Sciences Graduate Program (I.G.), Center for Applied Plant Sciences (I.G., Da.M.), Department of Plant Pathology (D.L.C.), and Department of Molecular Genetics (Da.M.), Ohio State University, Columbus, Ohio 43210; andCollege of Pharmacy, Research Institute of Pharmaceutical Science, Plant Molecular Biology and Biotechnology Research Center, Gyeongsang National University, Jinju 660-751, Republic of Korea (S.-M.P., M.G.K.).
Alvaro L Perez-QuinteroDepartment of Horticulture and Crop Science (J.E.A., J.L., A.L.P.-Q., Do.M., W.Z., J.J.B., Da.M.), Molecular and Cellular Imaging Center-Columbus, Ohio Agricultural Research and Development Center (J.L., S.O.O., J.J.B.), Translational Plant Sciences Graduate Program (I.G.), Center for Applied Plant Sciences (I.G., Da.M.), Department of Plant Pathology (D.L.C.), and Department of Molecular Genetics (Da.M.), Ohio State University, Columbus, Ohio 43210; andCollege of Pharmacy, Research Institute of Pharmaceutical Science, Plant Molecular Biology and Biotechnology Research Center, Gyeongsang National University, Jinju 660-751, Republic of Korea (S.-M.P., M.G.K.).
Irene GentzelDepartment of Horticulture and Crop Science (J.E.A., J.L., A.L.P.-Q., Do.M., W.Z., J.J.B., Da.M.), Molecular and Cellular Imaging Center-Columbus, Ohio Agricultural Research and Development Center (J.L., S.O.O., J.J.B.), Translational Plant Sciences Graduate Program (I.G.), Center for Applied Plant Sciences (I.G., Da.M.), Department of Plant Pathology (D.L.C.), and Department of Molecular Genetics (Da.M.), Ohio State University, Columbus, Ohio 43210; andCollege of Pharmacy, Research Institute of Pharmaceutical Science, Plant Molecular Biology and Biotechnology Research Center, Gyeongsang National University, Jinju 660-751, Republic of Korea (S.-M.P., M.G.K.).
Doris MajerczakDepartment of Horticulture and Crop Science (J.E.A., J.L., A.L.P.-Q., Do.M., W.Z., J.J.B., Da.M.), Molecular and Cellular Imaging Center-Columbus, Ohio Agricultural Research and Development Center (J.L., S.O.O., J.J.B.), Translational Plant Sciences Graduate Program (I.G.), Center for Applied Plant Sciences (I.G., Da.M.), Department of Plant Pathology (D.L.C.), and Department of Molecular Genetics (Da.M.), Ohio State University, Columbus, Ohio 43210; andCollege of Pharmacy, Research Institute of Pharmaceutical Science, Plant Molecular Biology and Biotechnology Research Center, Gyeongsang National University, Jinju 660-751, Republic of Korea (S.-M.P., M.G.K.).
Stephen O OpiyoDepartment of Horticulture and Crop Science (J.E.A., J.L., A.L.P.-Q., Do.M., W.Z., J.J.B., Da.M.), Molecular and Cellular Imaging Center-Columbus, Ohio Agricultural Research and Development Center (J.L., S.O.O., J.J.B.), Translational Plant Sciences Graduate Program (I.G.), Center for Applied Plant Sciences (I.G., Da.M.), Department of Plant Pathology (D.L.C.), and Department of Molecular Genetics (Da.M.), Ohio State University, Columbus, Ohio 43210; andCollege of Pharmacy, Research Institute of Pharmaceutical Science, Plant Molecular Biology and Biotechnology Research Center, Gyeongsang National University, Jinju 660-751, Republic of Korea (S.-M.P., M.G.K.).
Wanying ZhaoDepartment of Horticulture and Crop Science (J.E.A., J.L., A.L.P.-Q., Do.M., W.Z., J.J.B., Da.M.), Molecular and Cellular Imaging Center-Columbus, Ohio Agricultural Research and Development Center (J.L., S.O.O., J.J.B.), Translational Plant Sciences Graduate Program (I.G.), Center for Applied Plant Sciences (I.G., Da.M.), Department of Plant Pathology (D.L.C.), and Department of Molecular Genetics (Da.M.), Ohio State University, Columbus, Ohio 43210; andCollege of Pharmacy, Research Institute of Pharmaceutical Science, Plant Molecular Biology and Biotechnology Research Center, Gyeongsang National University, Jinju 660-751, Republic of Korea (S.-M.P., M.G.K.).
Seung-Mann PaekDepartment of Horticulture and Crop Science (J.E.A., J.L., A.L.P.-Q., Do.M., W.Z., J.J.B., Da.M.), Molecular and Cellular Imaging Center-Columbus, Ohio Agricultural Research and Development Center (J.L., S.O.O., J.J.B.), Translational Plant Sciences Graduate Program (I.G.), Center for Applied Plant Sciences (I.G., Da.M.), Department of Plant Pathology (D.L.C.), and Department of Molecular Genetics (Da.M.), Ohio State University, Columbus, Ohio 43210; andCollege of Pharmacy, Research Institute of Pharmaceutical Science, Plant Molecular Biology and Biotechnology Research Center, Gyeongsang National University, Jinju 660-751, Republic of Korea (S.-M.P., M.G.K.).
Min Gab KimDepartment of Horticulture and Crop Science (J.E.A., J.L., A.L.P.-Q., Do.M., W.Z., J.J.B., Da.M.), Molecular and Cellular Imaging Center-Columbus, Ohio Agricultural Research and Development Center (J.L., S.O.O., J.J.B.), Translational Plant Sciences Graduate Program (I.G.), Center for Applied Plant Sciences (I.G., Da.M.), Department of Plant Pathology (D.L.C.), and Department of Molecular Genetics (Da.M.), Ohio State University, Columbus, Ohio 43210; andCollege of Pharmacy, Research Institute of Pharmaceutical Science, Plant Molecular Biology and Biotechnology Research Center, Gyeongsang National University, Jinju 660-751, Republic of Korea (S.-M.P., M.G.K.).
David L CoplinDepartment of Horticulture and Crop Science (J.E.A., J.L., A.L.P.-Q., Do.M., W.Z., J.J.B., Da.M.), Molecular and Cellular Imaging Center-Columbus, Ohio Agricultural Research and Development Center (J.L., S.O.O., J.J.B.), Translational Plant Sciences Graduate Program (I.G.), Center for Applied Plant Sciences (I.G., Da.M.), Department of Plant Pathology (D.L.C.), and Department of Molecular Genetics (Da.M.), Ohio State University, Columbus, Ohio 43210; andCollege of Pharmacy, Research Institute of Pharmaceutical Science, Plant Molecular Biology and Biotechnology Research Center, Gyeongsang National University, Jinju 660-751, Republic of Korea (S.-M.P., M.G.K.).
Joshua J BlakesleeDepartment of Horticulture and Crop Science (J.E.A., J.L., A.L.P.-Q., Do.M., W.Z., J.J.B., Da.M.), Molecular and Cellular Imaging Center-Columbus, Ohio Agricultural Research and Development Center (J.L., S.O.O., J.J.B.), Translational Plant Sciences Graduate Program (I.G.), Center for Applied Plant Sciences (I.G., Da.M.), Department of Plant Pathology (D.L.C.), and Department of Molecular Genetics (Da.M.), Ohio State University, Columbus, Ohio 43210; andCollege of Pharmacy, Research Institute of Pharmaceutical Science, Plant Molecular Biology and Biotechnology Research Center, Gyeongsang National University, Jinju 660-751, Republic of Korea (S.-M.P., M.G.K.).
David MackeyDepartment of Horticulture and Crop Science (J.E.A., J.L., A.L.P.-Q., Do.M., W.Z., J.J.B., Da.M.), Molecular and Cellular Imaging Center-Columbus, Ohio Agricultural Research and Development Center (J.L., S.O.O., J.J.B.), Translational Plant Sciences Graduate Program (I.G.), Center for Applied Plant Sciences (I.G., Da.M.), Department of Plant Pathology (D.L.C.), and Department of Molecular Genetics (Da.M.), Ohio State University, Columbus, Ohio 43210; andCollege of Pharmacy, Research Institute of Pharmaceutical Science, Plant Molecular Biology and Biotechnology Research Center, Gyeongsang National University, Jinju 660-751, Republic of Korea (S.-M.P., M.G.K.) mackey.86@osu.edu.
Institute of Crop Science · JPPlant (United States) · USImaging Center · USThe Ohio State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

AvrE family type III effector proteins share the ability to suppress host defenses, induce disease-associated cell death, and promote bacterial growth. However, despite widespread contributions to numerous bacterial diseases in agriculturally important plants, the mode of action of these effectors remains largely unknown. WtsE is an AvrE family member required for the ability of Pantoea stewartii ssp. stewartii (Pnss) to proliferate efficiently and cause wilt and leaf blight symptoms in maize (Zea mays) plants. Notably, when WtsE is delivered by a heterologous system into the leaf cells of susceptible maize seedlings, it alone produces water-soaked disease symptoms reminiscent of those produced by Pnss. Thus, WtsE is a pathogenicity and virulence factor in maize, and an Escherichia coli heterologous delivery system can be used to study the activity of WtsE in isolation from other factors produced by Pnss. Transcriptional profiling of maize revealed the effects of WtsE, including induction of genes involved in secondary metabolism and suppression of genes involved in photosynthesis. Targeted metabolite quantification revealed that WtsE perturbs maize metabolism, including the induction of coumaroyl tyramine. The ability of mutant WtsE derivatives to elicit transcriptional and metabolic changes in susceptible maize seedlings correlated with their ability to promote disease. Furthermore, chemical inhibitors that block metabolic flux into the phenylpropanoid pathways targeted by WtsE also disrupted the pathogenicity and virulence activity of WtsE. While numerous metabolites produced downstream of the shikimate pathway are known to promote plant defense, our results indicate that misregulated induction of phenylpropanoid metabolism also can be used to promote pathogen virulence.

Indexed as

Bacterial Secretion SystemsBacterial ProteinsBiological AssayGene Expression Regulation, PlantGene OntologyGenome, PlantModels, BiologicalMutationPantoeaPhenylalanine Ammonia-LyasePropanolsSeedlingsShikimic AcidTranscription, GeneticTyramineVirulence1-phenylpropanolBacterial ProteinsBacterial Secretion SystemsPhenylalanine Ammonia-LyasePropanolsShikimic AcidTyramine

Identifiers

PMID25635112
PMCPMC4348765
OpenAlexW2037904265

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.