ArticleJournal of applied physiology (Bethesda, Md. : 1985)2015
Effects of skeletal unloading on the vasomotor properties of the rat femur principal nutrient artery.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Sitting foot: posture dependent changes of volume, edema and perfusion of the foot. A prospective interventional study with 27 volunteers.BMC musculoskeletal disorders · 2024Trial
- Effects of long-term voluntary wheel running and selective breeding for wheel running on femoral nutrient canals.Journal of anatomy · 2024Article
- The Effects of Simulated and Real Microgravity on Vascular Smooth Muscle Cells.Gravitational and space research : publication of the American Society for Gravitational and Space Research · 2024Article
- Effects of Posture and Walking on Tibial Vascular Hemodynamics Before and After 14 Days of Head-Down Bed Rest.JBMR plus · 2023Article
- Stromal Lineage Precursors from Rodent Femur and Tibia Bone Marrows after Hindlimb Unloading: Functional Ex Vivo Analysis.International journal of molecular sciences · 2023Article
- Bone loss after severe spinal cord injury coincides with reduced bone formation and precedes bone blood flow deficits.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Update on the effects of microgravity on the musculoskeletal system.NPJ microgravity · 2021Review
- Article
- Mechanical, hormonal and metabolic influences on blood vessels, blood flow and bone.The Journal of endocrinology · 2017Review
- Redox Signaling and Its Impact on Skeletal and Vascular Responses to Spaceflight.International journal of molecular sciences · 2017Review
- Insulin-Stimulated Bone Blood Flow and Bone Biomechanical Properties Are Compromised in Obese, Type 2 Diabetic OLETF Rats.JBMR plus · 2017Article
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Authors and funding
4 authors.
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Abstract
Spaceflight and prolonged bed rest induce deconditioning of the cardiovascular system and bone loss. Previous research has shown declines in femoral bone and marrow perfusion during unloading and with subsequent reloading in hindlimb-unloaded (HU) rats, an animal model of chronic disuse. We hypothesized that the attenuated bone and marrow perfusion may result from altered vasomotor properties of the bone resistance vasculature. Therefore, the purpose of this study was to determine the effects of unloading on the vasoconstrictor and vasodilator properties of the femoral principal nutrient artery (PNA), the main conduit for blood flow to the femur, in 2 wk HU and control (CON) rats. Vasoconstriction of the femoral PNA was assessed in vitro using norepinephrine, phenylephrine, clonidine, KCl, endothelin-1, arginine vasopressin, and myogenic responsiveness. Vasodilation through endothelium-dependent [acetylcholine, bradykinin, and flow-mediated dilation (FMD)] and endothelium-independent mechanisms [sodium nitroprusside (SNP) and adenosine] were also determined. Vasoconstrictor responsiveness of the PNA from HU rats was not enhanced through any of the mechanisms tested. Endothelium-dependent vasodilation to acetylcholine (CON, 86 ± 3%; HU, 48 ± 7% vasodilation) and FMD (CON, 61 ± 9%; HU, 11 ± 11% vasodilation) were attenuated in PNAs from HU rats, while responses to bradykinin were not different between groups. Endothelium-independent vasodilation to SNP and adenosine were not different between groups. These data indicate that unloading-induced decrements in bone and marrow perfusion and increases in vascular resistance are not the result of enhanced vasoconstrictor responsiveness of the bone resistance arteries but are associated with reductions in endothelium-dependent vasodilation.
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