ArticleJournal of applied physiology (Bethesda, Md. : 1985)2015
Exercise training reverses aging-induced impairment of myogenic constriction in skeletal muscle arterioles.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Thermo-tone: A newly revealed mechanism of blood flow regulation.Experimental physiology · 2026Review
- Mechanoreceptor-mediated adaptations to physical exercise: from acute responses to long-term training effects.Cellular and molecular life sciences : CMLS · 2026Review
- Arteries are finely tuned thermosensors regulating myogenic tone and blood flow.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Mechanical signaling regulates vascular smooth muscle cell adaptation in aging.Frontiers in physiology · 2025Article
- Pulmonary hypertension impairs vasomotor function in rat diaphragm arterioles.Microvascular research · 2024Article
- Functional, Structural and Proteomic Effects of Ageing in Resistance Arteries.International journal of molecular sciences · 2024Review
- The Effects of Simulated and Real Microgravity on Vascular Smooth Muscle Cells.Gravitational and space research : publication of the American Society for Gravitational and Space Research · 2024Article
- TRPV1 in arteries enables a rapid myogenic tone.The Journal of physiology · 2022Article
- Dynamic Crosstalk between Vascular Smooth Muscle Cells and the Aged Extracellular Matrix.International journal of molecular sciences · 2021Review
- Sarcopenia: Aging-Related Loss of Muscle Mass and Function.Physiological reviews · 2019 · on this mapReview
- Vascular Smooth Muscle Contractile Function Declines With Age in Skeletal Muscle Feed Arteries.Frontiers in physiology · 2018Article
- KMicrocirculation (New York, N.Y. : 1994) · 2018Review
- Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles.Comprehensive Physiology · 2017Review
- Effects of aging and exercise training on the dynamics of vasoconstriction in skeletal muscle resistance vessels.European journal of applied physiology · 2017Article
- Short-duration increases in intraluminal pressure improve vasoconstrictor responses in aged skeletal muscle feed arteries.European journal of applied physiology · 2016Article
- Heterogeneous ageing of skeletal muscle microvascular function.The Journal of physiology · 2016Article
- Physical activity-induced remodeling of vasculature in skeletal muscle: role in treatment of type 2 diabetes.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Review
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
To investigate whether exercise training can reverse age-related impairment of myogenic vasoconstriction in skeletal muscle arterioles, young (4 mo) and old (22 mo) male Fischer 344 rats were randomly assigned to either sedentary or exercise-trained groups. The roles of the endothelium and Kv1 channels in age- and exercise training-induced adaptations of myogenic responses were assessed through evaluation of pressure-induced constriction in endothelium-intact and denuded soleus muscle arterioles in the presence and absence of the Kv1 channel blocker, correolide. Exercise training enhanced myogenic constriction in arterioles from both old and young rats. In arterioles from old rats, exercise training restored myogenic constriction to a level similar to that of arterioles from young sedentary rats. Removal of the endothelium did not alter myogenic constriction of arterioles from young sedentary rats, but reduced myogenic constriction in arterioles from young exercise-trained rats. In contrast, endothelial removal had no effect on myogenic constriction of arterioles from old exercise-trained rats, but increased myogenic vasoconstriction in old sedentary rats. The effect of Kv1 channel blockade was also dependent on age and training status. In arterioles from young sedentary rats, Kv1 blockade had little effect on myogenic constriction, whereas in old sedentary rats Kv1 blockade increased myogenic constriction. After exercise training, Kv1 channel blockade increased myogenic constriction in arterioles from both young and old rats. Thus exercise training restores myogenic constriction of arterioles from old rats and enhances myogenic constriction from young rats through adaptations of the endothelium and smooth muscle Kv1 channels.
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