ArticleInvestigative ophthalmology & visual science2015
Steady-state contrast response functions provide a sensitive and objective index of amblyopic deficits.
Article in Investigative ophthalmology & visual science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Effects of stimulus size and contrast on binocular rivalry in adults with anisometropic amblyopia.Vision research · 2026Article
- Short-term amblyopic eye deprivation boosts the binocular intermodulation in anisometropic amblyopia.Frontiers in neuroscience · 2026Article
- Attenuated and delayed neural activity in cortical microcircuitry of monocular processing and binocular interactions in human amblyopia.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Article
- Meridional anisotropy in contrast sensitivity and visual evoked potential in adults with high myopic astigmatism.Frontiers in neuroscience · 2024Article
- Quantitative evaluation of anisometropic amblyopia treatment efficacy by coupling multiple visual functions via CRITIC algorithm.BMC ophthalmology · 2023Article
- Reduced interocular suppression after inverse patching in anisometropic amblyopia.Frontiers in neuroscience · 2023Article
- Article
- Steady-state measures of visual suppression.PLoS computational biology · 2021Article
- Stimulus dependence of interocular suppression.Scientific reports · 2021Article
- Neural markers of suppression in impaired binocular vision.NeuroImage · 2021Article
- Long-Range Interocular Suppression in Adults with Strabismic Amblyopia: A Pilot fMRI Study.Vision (Basel, Switzerland) · 2019Article
- Evidence for an Optimal Algorithm Underlying Signal Combination in Human Visual Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Covert spatial attention is functionally intact in amblyopic human adults.Journal of vision · 2016Article
- Unveiling Visual Physiology and Steady-State Evoked Potentials using Low-Cost and Transferable Electroencephalography for Evaluating Neuronal Activation.International journal of psychological researchArticle
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeVisual deficits in amblyopia are neural in origin, yet are difficult to characterize with functional magnetic resonance imagery (fMRI). Our aim was to develop an objective electroencephalography (EEG) paradigm that can be used to provide a clinically useful index of amblyopic deficits.
methodsWe used steady-state visual evoked potentials (SSVEPs) to measure full contrast response functions in both amblyopic (n = 10, strabismic or mixed amblyopia, mean age: 44 years) and control (n = 5, mean age: 31 years) observers, both with and without a dichoptic mask.
resultsAt the highest target contrast, the ratio of amplitudes across the weaker and stronger eyes was highly correlated (r = 0.76) with the acuity ratio between the eyes. We also found that the contrast response function in the amblyopic eye had both a greatly reduced amplitude and a shallower slope, but that surprisingly dichoptic masking was weaker than in controls. The results were compared with the predictions of a computational model of amblyopia and suggest a modification to the model whereby excitatory (but not suppressive) signals are attenuated in the amblyopic eye.
conclusionsWe suggest that SSVEPs offer a sensitive and objective measure of the ocular imbalance in amblyopia and could be used to assess the efficacy of amblyopia therapies currently under development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.