ArticleJournal of the American College of Cardiology2015
Autonomic control of heart rate and QT interval variability influences arrhythmic risk in long QT syndrome type 1.
Article in Journal of the American College of Cardiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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30 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.
- ExomeChip-Wide Analysis of 95 626 Individuals Identifies 10 Novel Loci Associated With QT and JT Intervals.Circulation. Genomic and precision medicine · 2018Pooled it
- Sleep, Neural Circulatory Control, and Cardiovascular Disease: A Mechanistic Review.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Influence of Night Shift Work on Heart Rate Variability in an Age- and Gender-Matched Study Group.Journal of cardiovascular development and disease · 2024Article
- Impact of surgical aortic valve replacement and transcatheter aortic valve implantation on cardiovascular and cerebrovascular controls: A pilot study.Physiological reports · 2024Article
- Holter study of heart rate variability in children and adolescents with long QT syndrome.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2024Article
- Article
- Radiofrequency catheter ablation in congenital long QT syndrome: an anatomical approach to a supposedly primary electrical disease.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023Article
- Article
- Increased sympathetic modulation in breast cancer survivors determined by measurement of heart rate variability.Scientific reports · 2022Article
- Short-Term Beat-to-Beat QT Variability Appears Influenced More Strongly by Recording Quality Than by Beat-to-Beat RR Variability.Frontiers in physiology · 2022Article
- Autonomic cardiac innervation: impact on the evolution of arrhythmias in inherited cardiac arrhythmia syndromes.Herzschrittmachertherapie & Elektrophysiologie · 2021Review
- Influence of Heart Rate Variability on Abstinence-Related Changes in Brain State in Everyday Drinkers.Brain sciences · 2021Article
- Diagnostic accuracy of the response to the brief tachycardia provoked by standing in children suspected for long QT syndrome.Heart rhythm O2 · 2021Article
- Ventricular repolarization instability quantified by instantaneous frequency of ECG ST intervals.Technology and health care : official journal of the European Society for Engineering and Medicine · 2021Article
- Heart Rate Influence on the QT Variability Risk Factors.Diagnostics (Basel, Switzerland) · 2020Article
- Autonomic and Cardiac Repolarization Lability in Long QT Syndrome Patients.Autonomic neuroscience : basic & clinical · 2020Article
- Rationale and design of the EMPYREAN study.ESC heart failure · 2020Article
- Head-up tilt test induces T-wave alternans in long QT syndrome with KCNQ1 gene mutation: Case report CARE-compliant article.Medicine · 2020Article
- Assessing Autonomic Function from Electrodermal Activity and Heart Rate Variability During Cold-Pressor Test and Emotional Challenge.Scientific reports · 2020Article
- Autonomic Control of the Heart and Its Clinical Impact. A Personal Perspective.Frontiers in physiology · 2020Article
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Authors and funding
8 authors at 6 institutions in 3 countries.
Funding
Abstract
backgroundA puzzling feature of the long QT syndrome (LQTS) is that family members carrying the same mutation often have divergent symptoms and clinical outcomes.
objectivesThis study tested the hypothesis that vagal and sympathetic control, as assessed by spectral analysis of spontaneous beat-to-beat variability of RR and QT intervals from standard 24-h electrocardiogram Holter recordings, could modulate the severity of LQTS type 1 (LQT1) in 46 members of a South-African LQT1 founder population carrying the clinically severe KCNQ1 A341V mutation.
methodsNonmutation carriers (NMCs) (n = 14) were compared with mutation carriers (MCs) (n = 32), 22 with and 10 without major symptoms. We assessed the effect of circadian rhythm and beta-blocker therapy over traditional time and frequency domain RR and QT variability indexes.
resultsThe asymptomatic MCs differed significantly from the symptomatic MCs and from NMCs in less vagal control of heart rate and more reactive sympathetic modulation of the QT interval, particularly during daytime when arrhythmia risk for patients with LQT1 is greatest.
conclusionsThe present data identified an additional factor contributing to the differential arrhythmic risk among patients with LQT1 carrying the same mutation. A healthy autonomic control confers a high risk, whereas patients with higher sympathetic control of the QT interval and reduced vagal control of heart rate are at lower risk. This differential "autonomic make-up," likely under genetic control, will allow refinement of risk stratification within families with LQTS, leading to more targeted management.
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