SynthesisAJNR. American journal of neuroradiology2015
Imaging biomarkers in acute ischemic stroke trials: a systematic review.
Synthesis in AJNR. American journal of neuroradiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Microstructural properties in subacute aphasia: concurrent and prospective relationships underpinning recovery.Brain structure & function · 2024Trial
- Thrombus Perviousness Is Associated With Differential Treatment Outcomes Following IVT and EVT in MeVO Stroke.Stroke · 2026Article
- Extensive ischemic change on stroke presentation is uncommon: A population-based study.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2025Article
- Estimation of Acute Infarct Core and Hypoperfused Region from Baseline Noncontrast Computed Tomography and Computed Tomography Angiography Scans of Patients with Ischemic Stroke.Stroke (Hoboken, N.J.) · 2025Article
- Integrated analysis of m6A regulator mediated RNA methylation and key immune related genes in ischemic stroke.Scientific reports · 2025Article
- Novel Computed Tomography Perfusion and Laboratory Indices as Predictors of Long-Term Outcome and Survival in Acute Ischemic Stroke.Neurology international · 2025Article
- A Review of emergency medical services for stroke.African health sciences · 2024Review
- Article
- Evaluating iron deposition in gray matter nuclei of patients with acute ischemic stroke using quantitative susceptibility mapping.Frontiers in neurology · 2024Article
- Article
- Identification of immune-related key genes in the peripheral blood of ischaemic stroke patients using a weighted gene coexpression network analysis and machine learning.Journal of translational medicine · 2022Article
- Clinical translation of amide proton transfer (APT) MRI for ischemic stroke: a systematic review (2003-2020).Quantitative imaging in medicine and surgery · 2021Review
- Weighted gene co expression network analysis (WGCNA) with key pathways and hub-genes related to micro RNAs in ischemic stroke.IET systems biology · 2021Article
- Hyperdense middle cerebral artery sign in large cerebral infarction.Brain and behavior · 2021Article
- Physcion Protects Rats Against Cerebral Ischemia-Reperfusion Injury via Inhibition of TLR4/NF-kB Signaling Pathway.Drug design, development and therapy · 2021Article
- Measurement of collateral perfusion in acute stroke: a vessel-encoded arterial spin labeling study.Scientific reports · 2019Article
- Quantifying Infarct Growth and Secondary Injury Volumes: Comparing Multimodal Image Registration Measures.Stroke · 2018Article
- Update on Neurocritical Care of Stroke.Current cardiology reports · 2017Review
- Optimizing image registration and infarct definition in stroke research.Annals of clinical and translational neurology · 2017Article
- Quantification of Serial Cerebral Blood Flow in Acute Stroke Using Arterial Spin Labeling.Stroke · 2017Observational
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Authors and funding
7 authors.
Funding
Abstract
background and purposeImaging biomarkers are increasingly used to provide a better understanding of the pathophysiology of acute ischemic stroke. However, this approach of routinely using imaging biomarkers to inform treatment decisions has yet to be translated into successful randomized trials. The aim of this study was to systematically review the use of imaging biomarkers in randomized controlled trials in patients with acute ischemic stroke, exploring the purposes for which the imaging biomarkers were used. MATERIALS AND
methodsWe performed a systematic review of imaging biomarkers used in randomized controlled trials of acute ischemic stroke, in which a therapeutic intervention was trialed within 48 hours of symptom onset. Data bases searched included MEDLINE, EMBASE, strokecenter.org, and the Virtual International Stroke Trials Archive (1995-2014).
resultsEighty-four studies met the criteria, of which 49 used imaging to select patients; 31, for subgroup analysis; and 49, as an outcome measure. Imaging biomarkers were broadly used for 8 purposes. There was marked heterogeneity in the definitions and uses of imaging biomarkers and significant publication bias among post hoc analyses.
conclusionsImaging biomarkers offer the opportunity to refine the trial cohort by minimizing participant variation, to decrease sample size, and to personalize treatment approaches for those who stand to benefit most. However, within imaging modalities, there has been little consistency between stroke trials. Greater effort to prospectively use consistent imaging biomarkers should help improve the development of novel treatment strategies in acute stroke and improve comparison between studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.