ArticleBiomechanics and modeling in mechanobiology2015
Multi-view stereo analysis reveals anisotropy of prestrain, deformation, and growth in living skin.
Article in Biomechanics and modeling in mechanobiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- The Histological and Mechanical Behavior of Skin During Puncture for Different Impactor Sizes and Loading Rates.Annals of biomedical engineering · 2025Article
- Numerical investigation of new rete ridge formation in a multi-layer model of skin subjected to tissue expansion.Journal of biomechanics · 2024Article
- A machine learning approach to predict in vivo skin growth.Scientific reports · 2024Article
- A machine learning approach to predictResearch square · 2024Article
- Bayesian Inference With Gaussian Process Surrogates to Characterize Anisotropic Mechanical Properties of Skin From Suction Tests.Journal of biomechanical engineering · 2022Article
- Benchtop characterization of the tricuspid valve leaflet pre-strains.Acta biomaterialia · 2022Article
- Bayesian calibration of a computational model of tissue expansion based on a porcine animal model.Acta biomaterialia · 2022Article
- Improving reconstructive surgery design using Gaussian process surrogates to capture material behavior uncertainty.Journal of the mechanical behavior of biomedical materials · 2021Article
- Personalized Computational Models of Tissue-Rearrangement in the Scalp Predict the Mechanical Stress Signature of Rotation Flaps.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2021Article
- The Geometry of Incompatibility in Growing Soft Tissues: Theory and Numerical Characterization.Journal of the mechanics and physics of solids · 2021Article
- Propagation of uncertainty in the mechanical and biological response of growing tissues using multi-fidelity Gaussian process regression.Computer methods in applied mechanics and engineering · 2020Article
- Improving tissue expansion protocols through computational modeling.Journal of the mechanical behavior of biomedical materials · 2018Article
- Determining the Differential Effects of Stretch and Growth in Tissue-Expanded Skin: Combining Isogeometric Analysis and Continuum Mechanics in a Porcine Model.Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2018Article
- Quantification of Strain in a Porcine Model of Skin Expansion Using Multi-View Stereo and Isogeometric Kinematics.Journal of visualized experiments : JoVE · 2017Article
- The Incompatibility of Living Systems: Characterizing Growth-Induced Incompatibilities in Expanded Skin.Annals of biomedical engineering · 2016Article
- Isogeometric Kirchhoff-Love shell formulations for biological membranes.Computer methods in applied mechanics and engineering · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Skin expansion delivers newly grown skin that maintains histological and mechanical features of the original tissue. Although it is the gold standard for cutaneous defect correction today, the underlying mechanisms remain poorly understood. Here we present a novel technique to quantify anisotropic prestrain, deformation, and growth in a porcine skin expansion model. Building on our recently proposed method, we combine two novel technologies, multi-view stereo and isogeometric analysis, to characterize skin kinematics: Upon explantation, a unit square retracts ex vivo to a square of average dimensions of [Formula: see text]. Upon expansion, the unit square deforms in vivo into a rectangle of average dimensions of [Formula: see text]. Deformations are larger parallel than perpendicular to the dorsal midline suggesting that skin responds anisotropically with smaller deformations along the skin tension lines. Upon expansion, the patch grows in vivo by [Formula: see text] with respect to the explanted, unexpanded state. Growth is larger parallel than perpendicular to the midline, suggesting that elevated stretch activates mechanotransduction pathways to stimulate tissue growth. The proposed method provides a powerful tool to characterize the kinematics of living skin. Our results shed light on the mechanobiology of skin and help us to better understand and optimize clinically relevant procedures in plastic and reconstructive surgery.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.