ArticleAmerican journal of ophthalmology2015
Assessment of retinal nerve fiber layer thickness in healthy, full-term neonates.
Article in American journal of ophthalmology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Normative data for optical coherence tomography in children: a systematic review.Eye (London, England) · 2021Pooled it
- Very Preterm Infant Retinal Microanatomy at 36 Weeks' Postmenstrual Age and 2-Year Neurodevelopment.JAMA ophthalmology · 2026Article
- Normative optical coherence tomography reference ranges of the optic nerve head, nerve fiber layer, and macula in healthy Saudi children.Saudi medical journal · 2023Article
- Retinal Nerve Fiber Layer Imaging with Two Different Spectral Domain Optical Coherence Tomographs: Normative Data for Romanian Children.Diagnostics (Basel, Switzerland) · 2023Article
- Preterm infant retinal OCT markers of perinatal health and retinopathy of prematurity.Frontiers in pediatrics · 2023Review
- Insights into the developing fovea revealed by imaging.Progress in retinal and eye research · 2022Review
- Depth-resolved extraction of optical attenuation for glaucoma assessment in clinical settings: a pilot study.Biomedical optics express · 2022Article
- Association Between Retinal Microanatomy in Preterm Infants and 9-Month Visual Acuity.JAMA ophthalmology · 2022Observational
- Segmentation of the foveal and parafoveal retinal architecture using handheld spectral-domain optical coherence tomography in children with Down syndrome.Eye (London, England) · 2022Article
- Birth Weight Is a Significant Predictor of Retinal Nerve Fiber Layer Thickness at 36 Weeks Postmenstrual Age in Preterm Infants.American journal of ophthalmology · 2021Observational
- Repeatability and Reproducibility of Axial and Lateral Measurements on Handheld Optical Coherence Tomography Systems Compared with Tabletop System.Translational vision science & technology · 2020Article
- Subclinical Retinal versus Brain Findings in Infants with Hypoxic Ischemic Encephalopathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020Article
- Reliability and Recommended Settings for Pediatric Circumpapillary Retinal Nerve Fiber Layer Imaging Using Hand-Held Optical Coherence Tomography.Translational vision science & technology · 2020Article
- Reliability of Handheld Optical Coherence Tomography in Children Younger Than Three Years of Age Undergoing Vigabatrin Treatment for Childhood Epilepsy.Translational vision science & technology · 2020Article
- The Horizontal Raphe of the Human Retina and its Watershed Zones.Vision (Basel, Switzerland) · 2019Review
- Optic Nerve Head Development in Healthy Infants and Children Using Handheld Spectral-Domain Optical Coherence Tomography.Ophthalmology · 2016Article
- Optical coherence tomography of the preterm eye: from retinopathy of prematurity to brain development.Eye and brain · 2016Review
- Thinner Retinal Nerve Fiber Layer in Very Preterm Versus Term Infants and Relationship to Brain Anatomy and Neurodevelopment.American journal of ophthalmology · 2015Article
- Retinal Imaging of Infants on Spectral Domain Optical Coherence Tomography.BioMed research international · 2015Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
purposeTo measure average retinal nerve fiber layer (RNFL) thicknesses in healthy, full-term neonates.
designDescriptive research to develop normative data.
methodsHealthy infants born between 37 and 42 weeks postmenstrual age were imaged with hand-held spectral-domain optical coherence tomography. A custom script segmented the RNFL; the fovea and optic nerve center were manually selected. A second script measured the average RNFL thickness along the papillomacular bundle, defined as the arc from -15 degrees to +15 degrees on the axis from the optic nerve to fovea, with radii of 1.1, 1.3, 1.5, and 1.7 mm from the center of the optic disc. Shapiro-Wilk W tests assessed these measurements for normality to determine the age-appropriate radial distance for subsequent analyses. Average RNFL thicknesses for four temporal 45-degree sectors (superior temporal, temporal superior, temporal inferior, and inferior temporal) and the temporal quadrant were calculated and compared to demographic parameters for all infants.
resultsFifty full-term infants were adequately imaged for RNFL analysis. RNFL thicknesses at 1.5 mm radial distance from the optic nerve were the most normally distributed. While there was a trend toward greater mean superior temporal RNFL thickness for both black and Hispanic vs white infants (128 ± 27 μm, 124 ± 30 μm, and 100 ± 19 μm, respectively, P = .04 for both comparisons), there were no other significant differences noted in RNFL thicknesses by race, sex, gestational age, or birth weight.
conclusionsWe present RNFL thickness measurements for healthy, full-term infants that may serve as normative data for future analyses.
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