ArticleJournal of perinatology : official journal of the California Perinatal Association2015
A comprehensive study of umbilical cord blood cell developmental changes and reference ranges by gestation, gender and mode of delivery.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The trial behind it
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Who cites it
25 citing papers in PubMed.
- Impact of prenatal pyrethroid pesticide exposure on neonatal lymphocyte subsets and apoptosis: a birth cohort study.Journal of global health · 2026Article
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- Value of red blood cell distribution width in evaluating 2019-nCoV infection in neonates: a retrospective study.Scientific reports · 2025Article
- Effect of delivery mode on postnatal platelet count dynamics in neonates born to mothers with immune thrombocytopenia.International journal of hematology · 2023Article
- Nucleated red blood cells explain most of the association between DNA methylation and gestational age.Communications biology · 2023Article
- Drug exposure during pregnancy: Current understanding and approaches to measure maternal-fetal drug exposure.Frontiers in pharmacology · 2023Review
- Gestational Diabetes Melitus and Cord Blood Platelet Function Studied via the PFA-100 System.Diagnostics (Basel, Switzerland) · 2022Article
- Umbilical cord blood hematological parameters reference interval for newborns from Addis Ababa, Ethiopia.BMC pediatrics · 2021Article
- Article
- Human Umbilical Cord: Information Mine in Sex-Specific Medicine.Life (Basel, Switzerland) · 2021Review
- Capillary blood reference intervals for platelet parameters in healthy full-term neonates in China.BMC pediatrics · 2020Article
- Hematological reference intervals among full-term newborns in Ethiopia: a cross-sectional study.BMC pediatrics · 2020Article
- Assessment of Placental Disposition of Infliximab and Etanercept in Women With Autoimmune Diseases and in the Ex Vivo Perfused Placenta.Clinical pharmacology and therapeutics · 2020Article
- Substrates and Clearance Products of Fetal Adrenal Glucocorticoid Synthesis in Full-Term Human Umbilical Circulation.Journal of the Endocrine Society · 2020Article
- Does cesarean delivery impact infant weight gain and adiposity over the first year of life?International journal of obesity (2005) · 2019Article
- BLOOD CELLS PROFILE IN UMBILICAL CORD OF LATE PRETERM AND TERM NEWBORNS.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2019Article
- Copenhagen Baby Heart Study: a population study of newborns with prenatal inclusion.European journal of epidemiology · 2019Article
- Italian Recommendations for Placental Transfusion Strategies.Frontiers in pediatrics · 2018Review
- Effect of Genotype and Maternal Affective Disorder on Intronic Methylation of FK506 Binding Protein 5 in Cord Blood DNA.Frontiers in genetics · 2018Article
- Response of cord blood cells to environmental, hereditary and perinatal factors: A prospective birth cohort study.PloS one · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe purpose of this study was to determine the normal hematological values in cord blood during gestation, the impact of the type of delivery and differences in gender. STUDY
designThe database included 10 287 live births of 30-44 weeks gestation from cesarean or vaginal deliveries. Cord blood was collected into bags containing lyophilized heparin. Specimens were stored for 24 h or less and analyzed using the SysmexXE-2100. Data from cesarean births were used to evaluate developmental hematopoietic changes.
resultIncreases during maturation occurred in hemoglobin, hematocrit, red blood cell count, and decreases in mean corpuscular volume and mean corpuscular hemoglobin. The number of nucleated red blood cells per 100 white blood cells decreased but absolute counts remained constant. Quantitative counts of white blood cells, neutrophils, monocytes (MON), eosinophils and lymphocytes (LYMP) increased, but percentages of lymphocytes and monocytes decreased. Platelets increased from 30-35 weeks.
conclusionReference ranges were established for cord blood. Erythroid and myeloid cells show developmental changes. Mode of delivery has a significant effect on hematologic values. Only a rare parameter showed differences based on gender. The cord blood complete blood cell count has the potential for providing relevant clinical information for managing neonatal patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.