ArticleChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2015
A cytogenetic and comparative map of camelid chromosome 36 and the minute in alpacas.
Article in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 19 citations in OpenAlex.
- Advances in the Diagnosis of Reproductive Disorders in Female Camelids.Animals : an open access journal from MDPI · 2025Review
- Clinical and Histological Features of Ovarian Hypoplasia/Dysgenesis in Alpacas.Frontiers in veterinary science · 2022Article
- Article
- Chromosome-Level Alpaca Reference GenomeFrontiers in genetics · 2019Article
- An Autosomal Translocation 73,XY,t(12;20)(q11;q11) in an Infertile Male Llama (Frontiers in genetics · 2019Article
- Chromosomal Localization of Candidate Genes for Fiber Growth and Color in Alpaca (Frontiers in genetics · 2019Article
- Construction of two whole genome radiation hybrid panels for dromedary (Camelus dromedarius): 5000Scientific reports · 2018Article
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Authors and funding
9 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent advances in camelid genomics have provided draft sequence assemblies and the first comparative and gene maps for the dromedary (CDR) and the alpaca (LPA). However, no map information is currently available for the smallest camelid autosome-chr36. The chromosome is also of clinical interest because of its involvement in the minute chromosome syndrome (MCS) in infertile alpacas. Here, we developed molecular markers for camelid chr36 by direct sequencing CDR36 and LPA minute and by bioinformatics analysis of alpaca unplaced sequence scaffolds. We constructed a cytogenetic map for chr36 in the alpaca, llama, and dromedary and showed its homology to human chromosome 7 (HSA7) at 49.8-55.5 Mb. The chr36 map comprised seven markers, including two genes-ZPBP and WVC2. Comparative status of HSA7 was further refined by cytogenetic mapping of 16 HSA7 orthologs in camelid chromosomes 7 and 18 and by the analysis of HSA7-conserved synteny blocks across 11 vertebrate species. Finally, mapping chr36 markers in infertile alpacas confirmed that the minute chromosome was a derivative of chr36, but the small size was not a result of a large deletion or a translocation. Instead, cytogenetic mapping of 5.8S, 18S, and 28S rRNA genes (nucleolus organizer region (NOR)) revealed that the size difference between chr36 homologs in infertile alpacas was due to a heterozygous presence of NOR, whereas chr36 in fertile alpacas had no NOR. We theorized that the heterozygous NOR might affect chr36 pairing, recombination, and segregation in meiosis and, thus fertility.
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