ArticleThe Journal of investigative dermatology2015
NKG2D-dependent activation of dendritic epidermal T cells in contact hypersensitivity.
Article in The Journal of investigative dermatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- Review
- Roles of dendritic epidermal T cells in steady and different pathological states.Burns & trauma · 2025Review
- Gut Microbiota Regulates the Homeostasis of Dendritic Epidermal T Cells.Life (Basel, Switzerland) · 2024Article
- High-sensitive sensory neurons exacerbate rosacea-like dermatitis in mice by activating γδ T cells directly.Nature communications · 2024Article
- The current state of knowledge on the role of NKG2D ligands in multiple sclerosis and other autoimmune diseases.Frontiers in molecular neuroscience · 2024Review
- The junctional adhesion molecule-like protein (JAML) is important for the inflammatory response during contact hypersensitivity.Contact dermatitis · 2023Article
- γδ T Cell‒Mediated Wound Healing Is Diminished by Allergic Skin Inflammation.The Journal of investigative dermatology · 2022Article
- MULT1-Encoding DNA Alleviates Schistosomiasis-Associated Hepatic Fibrosis via Modulating Cellular Immune Response.Journal of inflammation research · 2022Article
- γδ T cell costimulatory ligands in antitumor immunity.Exploration of immunology · 2022Article
- The molecular mechanisms supporting the homeostasis and activation of dendritic epidermal T cell and its role in promoting wound healing.Burns & trauma · 2021Review
- Epidermal resident γδ T cell development and function in skin.Cellular and molecular life sciences : CMLS · 2021Review
- AHR Signaling Dampens Inflammatory Signature in Neonatal Skin γδ T Cells.International journal of molecular sciences · 2020Article
- Review
- Get in Touch With Dendritic Epithelial T Cells!Frontiers in immunology · 2020Review
- Dendritic Epidermal T Cells in Allergic Contact Dermatitis.Frontiers in immunology · 2020Review
- Role of Dendritic Epidermal T Cells in Cutaneous Carcinoma.Frontiers in immunology · 2020Review
- Recent advances in understanding and managing contact dermatitis.F1000Research · 2018Review
- The NKG2D/NKG2DL Axis in the Crosstalk Between Lymphoid and Myeloid Cells in Health and Disease.Frontiers in immunology · 2018Review
- Coreceptors and Their Ligands in Epithelial γδ T Cell Biology.Frontiers in immunology · 2018Review
- Emerging Skin T-Cell Functions in Response to Environmental Insults.The Journal of investigative dermatology · 2017Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
The interaction between keratinocytes (KCs) and skin-resident immune cells has an important role in induction of contact hypersensitivity. A specific subset of γδ T cells termed dendritic epidermal T cells (DETCs) are located in mouse epidermis, and we have recently shown that DETCs become activated and produce IL-17 in an IL-1β-dependent manner during contact hypersensitivity. Various receptors on DETCs, including NKG2D, are involved in DETC responses against tumors and during wound healing. The ligands for NKG2D (NKG2DL) are stress-induced proteins such as mouse UL16-binding protein-like transcript 1 (Mult-1), histocompatibility 60 (H60), and retinoic acid early inducible-1 (Rae-1) in mice and major histocompatibility complex (MHC) class I-chain-related A (MICA), MHC class I-chain-related B, and UL16-binding protein in humans. Here, we show that allergens upregulate expression of the NKG2DL Mult-1, H60, and Rae-1 in cultured mouse KCs and of MICA in primary human KCs. We demonstrate that Mult-1 is expressed in mouse skin exposed to allergen. Furthermore, we find that the vast majority of DETCs in murine epidermis and skin-homing cutaneous lymphocyte-associated antigen positive γδ T cells in humans express NKG2D. Finally, we demonstrate that blocking of NKG2D partially inhibits allergen-induced DETC activation. These findings demonstrate that NKG2D and NKG2DL are involved in allergen-induced activation of DETCs and indicate that the NKG2D/NKG2DL pathway might be a potential target for treatment of contact hypersensitivity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.