ArticleClinical and experimental nephrology2015
Longitudinal relationships of metabolic syndrome and obesity with kidney function: Healthy Twin Study.
Article in Clinical and experimental nephrology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Obesity as a predictive factor for chronic kidney disease in adults: systematic review and meta-analysis.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2021Pooled it
- Metabolic phenotypes of obese, overweight, and normal weight individuals and risk of chronic kidney disease: a systematic review and meta-analysis.Archives of endocrinology and metabolism · 2019Pooled it
- Pooled it
- Review
- The Effect of Metabolic Syndrome and Its Individual Components on Renal Function: A Meta-Analysis.Journal of clinical medicine · 2023Review
- Review
- Article
- Lifestyle-Related Risk Factors for the Incidence and Progression of Chronic Kidney Disease in the Healthy Young and Middle-Aged Population.Nutrients · 2022Review
- The Heritability of Kidney Function Using an Older Australian Twin Population.Kidney international reports · 2022Article
- Article
- Impact of Obesity in Kidney Diseases.Nutrients · 2021Review
- Changes in metabolic syndrome status affect the incidence of end-stage renal disease in the general population: a nationwide cohort study.Scientific reports · 2021Article
- Relationship between abdominal adiposity and incident chronic kidney disease in young- to middle-aged working men: a retrospective cohort study.Clinical and experimental nephrology · 2019Article
- Metabolically Healthy Obesity and Risk of Kidney Function Decline.Obesity (Silver Spring, Md.) · 2018Article
- Genetic and environmental influences on the associations between change in kidney function and changes in cardiometabolic factors in Koreans.Clinical and experimental nephrology · 2017Article
- The kidney in obesity.Current hypertension reports · 2015Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo examine cross-sectional and longitudinal relationships, including genetic and environmental correlations, of metabolic syndrome (MetS) and obesity with kidney function.
methodsSubjects were 3,437 Korean adults of the Healthy Twin Study for cross-sectional relationships and 1,881 participants for longitudinal relationships (follow-up interval 3.7 ± 1.4 years). Obesity (body mass index ≥ 25 vs. <25 kg/m(2)), MetS, and chronic kidney disease [CKD; estimated glomerular filtration rate (eGFR) (<60 mL/min/1.73 m(2) using the modification of diet in renal disease study equation)] were categorized at baseline and follow-up.
resultsThe prevalence and incidence of chronic kidney disease were 2.5 and 3.3 %, respectively. Compared to individuals without obesity and MetS, prevalent CKD was associated with MetS regardless of weight status [adjusted odds ratio (AOR) 4.19 for those with MetS but without obesity; AOR 4.63 for those with MetS and obesity]. Incident CKD was associated with obesity regardless of baseline metabolic status (AOR 2.03 for those with obesity but without MetS; AOR 2.85 for those with obesity and MetS). MetS at follow-up was associated with incident CKD regardless of baseline MetS (AOR 2.42-2.52). Sex-adjusted bivariate analyses show inverse environmental correlations of the number of MetS components and BMI at baseline, with eGFR at baseline and follow-up (ρ E, -0.26 to -0.42, P < 0.001).
conclusionsMetS predicts prevalent CKD regardless of obesity, and obesity predicts incident CKD regardless of baseline MetS. Incident CKD is also associated with MetS at follow-up regardless of baseline MetS. These associations appear to be explained by shared environmental factors.
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