ArticleMedicine2015
Olfactory function and quality of life following microscopic endonasal transsphenoidal pituitary surgery.
Article in Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Olfactory outcomes after endonasal skull base surgery: a systematic review.Neurosurgical review · 2021Pooled it
- Persistent Olfactory Dysfunction Three Years After COVID-19: A Multicenter Observational Study.Pathogens (Basel, Switzerland) · 2026Observational
- A core outcome set for pituitary surgery research: an international delphi consensus study.Pituitary · 2025Article
- Prospective Study on Coblation Vs. Cautery in Endoscopic Trans Sphenoidal Surgery for Pituitary Macroadenoma: Impact on Nasal Function.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024Article
- Incidence and influencing factors of olfactory dysfunction in patients 1 week after endoscopic transsphenoidal resection of pituitary tumor: a cross-sectional study of 158 patients.Frontiers in neurology · 2024Article
- Remission, complications, and overall survival in transsphenoidal pituitary surgery-a Swedish single-center experience of 578 patients.Acta neurochirurgica · 2023Article
- Quality of Life Considerations in Endoscopic Endonasal Management of Anterior Cranial Base Tumors.Cancers · 2022Review
- Sinonasal Symptoms and Self-Reported Health before and after Endoscopic Pituitary Surgery-A Prospective Study.Journal of neurological surgery. Part B, Skull base · 2022Article
- Sinonasal outcomes associated with the use of BioGlue® in endoscopic transsphenoidal pituitary surgery.Neurosurgical review · 2022Article
- Equivalent outcomes in nasal symptoms following microscopic or endoscopic transsphenoidal surgery: results from multi-centre, prospective study.Acta neurochirurgica · 2022Article
- Quality-of-life evaluation for patients submitted to nasal endoscopic surgery for resection of pituitary tumours.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021Article
- Quality of Life and Sleep in Patients with Pituitary Adenoma in Relation to Tumor Type and Compression of the Optic Chiasm.Journal of clinical medicine · 2021Article
- Quality of Life and Morbidity after Endoscopic Endonasal Skull Base Surgeries Using the Sinonasal Outcomes Test (SNOT): A Tertiary Hospital Experience.International journal of otolaryngology · 2021Article
- Olfactory function in patients after transsphenoidal surgery for pituitary adenomas-a short review.Neurosurgical review · 2019Review
- Article
- How non-functioning pituitary adenomas can affect health-related quality of life: a conceptual model and literature review.Pituitary · 2018Review
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Olfactory outcomes as well as oronasal postoperative complications of transsphenoidal pituitary surgery have not been well studied. The objective of this study was to investigate nasal symptoms including olfactory function as well as quality of life following transsphenoidal pituitary surgery. The study is designed as a prospective cohort study set in a single tertiary hospital. A total of 53 patients with pituitary adenomas were included. All patients underwent pituitary surgery with the right-sided endonasal transsphenoidal approach. Outcomes were assessed with the Chinese version of the Medical Outcomes Study Short Form-36 (SF-36) to survey patient health, the Chinese version of the 22-item Sinonasal Outcome Test (SNOT-22), and a Toyota and Takagi (T&T) olfactometer. Assessments were carried out before surgery and at 1 week, and 1 and 4 months after surgery. The overall SF-36 scores were significantly lower, but the SNOT-22 scores were higher at 1 week and 1 month postoperatively compared with baseline (all P < 0.001). The results of T&T olfactometer testing showed that there was a significant decline in the ability to detect odors postoperatively, even at 4 months. Multivariate linear regression analysis showed that lower education level, partial tumor removal, and longer duration of surgery were independent risk factors for a higher SNOT-22 score at 1 week after surgery. The findings show that microscopic endonasal transsphenoidal pituitary surgery impairs olfactory function in most patients for at least 4 months after surgery.
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