ArticleHuman genetics2015
Differential positive selection of malaria resistance genes in three indigenous populations of Peninsular Malaysia.
Article in Human genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Article
- Natural selection and adaptive traits in the Maniq, a nomadic hunter-gatherer society from Mainland Southeast Asia.Scientific reports · 2025Article
- High-coverage whole-genome sequencing of a Jakun individual from the "Orang Asli" Proto-Malay subtribe from Peninsular Malaysia.Human genome variation · 2025Article
- A genotype imputation reference panel specific for native Southeast Asian populations.NPJ genomic medicine · 2024Article
- Population-specific positive selection on low CR1 expression in malaria-endemic regions.PloS one · 2023Article
- Genetic Connections and Convergent Evolution of Tropical Indigenous Peoples in Asia.Molecular biology and evolution · 2022Article
- The Peopling and Migration History of the Natives in Peninsular Malaysia and Borneo: A Glimpse on the Studies Over the Past 100 years.Frontiers in genetics · 2022Review
- Perceptions and prevention practices on malaria among the indigenous Orang Asli community in Kelantan, Peninsular Malaysia.Malaria journal · 2021Article
- Identifying adaptive alleles in the human genome: from selection mapping to functional validation.Human genetics · 2021Review
- Shared Signature of Recent Positive Selection on the TSBP1-BTNL2-HLA-DRA Genes in Five Native Populations from North Borneo.Genome biology and evolution · 2020Article
- Analysis of five deep-sequenced trio-genomes of the Peninsular Malaysia Orang Asli and North Borneo populations.BMC genomics · 2019Article
- Natural selection and local adaptation of blood pressure regulation and their perspectives on precision medicine in hypertension.Hereditas · 2019Review
- Observational study of the status of coronary risk biomarkers among Negritos with metabolic syndrome in the east coast of Malaysia.BMJ open · 2018Observational
- A genome-wide characterization of copy number variations in native populations of Peninsular Malaysia.European journal of human genetics : EJHG · 2018Article
- Genomic structure of the native inhabitants of Peninsular Malaysia and North Borneo suggests complex human population history in Southeast Asia.Human genetics · 2018Article
- Establishing multiple omics baselines for three Southeast Asian populations in the Singapore Integrative Omics Study.Nature communications · 2017Article
- Discerning the Origins of the Negritos, First Sundaland People: Deep Divergence and Archaic Admixture.Genome biology and evolution · 2017Article
- Characterising private and shared signatures of positive selection in 37 Asian populations.European journal of human genetics : EJHG · 2017Article
- Environmental Correlation Analysis for Genes Associated with Protection against Malaria.Molecular biology and evolution · 2016Article
- Ancestry, admixture and fitness in Colombian genomes.Scientific reports · 2015Article
Corrections and comments
- Erratum issuedErratum to: Differential positive selection of malaria resistance genes in three indigenous populations of Peninsular Malaysia.2015 · Ghazali, Fadzilah [corrected to Nor, Fadzilah Mohd]
Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The indigenous populations from Peninsular Malaysia, locally known as Orang Asli, continue to adopt an agro-subsistence nomadic lifestyle, residing primarily within natural jungle habitats. Leading a hunter-gatherer lifestyle in a tropical jungle environment, the Orang Asli are routinely exposed to malaria. Here we surveyed the genetic architecture of individuals from four Orang Asli tribes with high-density genotyping across more than 2.5 million polymorphisms. These tribes reside in different geographical locations in Peninsular Malaysia and belong to three main ethno-linguistic groups, where there is minimal interaction between the tribes. We first dissect the genetic diversity and admixture between the tribes and with neighboring urban populations. Later, by implementing five metrics, we investigated the genome-wide signatures for positive natural selection of these Orang Asli, respectively. Finally, we searched for evidence of genomic adaptation to the pressure of malaria infection. We observed that different evolutionary responses might have emerged in the different Orang Asli communities to mitigate malaria infection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.