Evidence map›Paper›PMID 25633979›Full record

ArticleGenes and immunity

Immunogenetic influences on acquisition of HIV-1 infection: consensus findings from two African cohorts point to an enhancer element in IL19 (1q32.2).

X Li, K Zhang, N M Pajewski, I Brill, H A Prentice, S Shrestha, W Kilembe, E Karita, S Allen, E Hunter and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes and immunity. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

X LiDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
K ZhangDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA.
N M PajewskiDepartment of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
I BrillDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
H A PrenticeDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
S ShresthaDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
W KilembeZambia-Emory HIV-1 Research Project, Lusaka, Zambia.
E KaritaProject San Francisco, Kigali, Rwanda.
S Allen1] Project San Francisco, Kigali, Rwanda [2] Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA.
E HunterEmory Vaccine Center, Emory University, Atlanta, GA, USA.
R A KaslowDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
J TangDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA.
University of Alabama at Birmingham · USEmory University · USWake Forest University · US

Funding

YNPRC NHP CLINICAL MEDICINE RESIDENCY PROGRAM - SUPPLEMENTP51RR000165 · NCRR · EMORY UNIVERSITY · PI ALTMAN, JOHN DAVID · 1985 to 2011
$114.0M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025008 · NCRR · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2007 to 2011
$29.0M
CTL and HIV Polymorphisms in Heterosexual TransmissionR01AI064060 · NIAID · EMORY UNIVERSITY · PI GOEPFERT, PAUL A., HUNTER, ERIC · 2005 to 2019
$21.7M
Host Genetic Epidemiology in HIV-1-Discordant African Couples and Other CohortsR01AI071906 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI TANG, JIANMING · 2008 to 2012
$3.8M
NCRR NIH HHS P51 RR000165NCRR NIH HHS UL1 RR025008NIAID NIH HHS AI064060NIAID NIH HHS R01 AI064060NIAID NIH HHS R01 AI071906
6 · The paper itself

Abstract

Numerous reports have suggested that immunogenetic factors may influence human immunodeficiency virus (HIV)-1 acquisition, yet replicated findings that translate between study cohorts remain elusive. Our work aimed to test several hypotheses about genetic variants within the IL10-IL24 gene cluster that encodes interleukin (IL)-10, IL-19, IL-20 and IL-24. In aggregated data from 515 Rwandans and 762 Zambians with up to 12 years of follow-up, 190 single-nucleotide polymorphisms passed quality control procedures. When HIV-1-exposed seronegative subjects (n=486) were compared with newly seroconverted individuals (n=313) and seroprevalent subjects (n=478) who were already infected at enrollment, rs12407485 (G>A) in IL19 showed a robust association signal in adjusted logistic regression models (odds ratio=0.64, P=1.7 × 10(-4) and q=0.033). Sensitivity analyses demonstrated that (i) results from both cohorts and subgroups within each cohort were highly consistent; (ii) verification of HIV-1 infection status after enrollment was critical; and (iii) supporting evidence was readily obtained from Cox proportional hazards models. Data from public databases indicate that rs12407485 is part of an enhancer element for three transcription factors. Overall, these findings suggest that molecular features at the IL19 locus may modestly alter the establishment of HIV-1 infection.

Indexed as

Chromosomes, Human, Pair 1Disease SusceptibilityEnhancer Elements, GeneticAdultAllelesBlack PeopleCohort StudiesComputational BiologyFemaleFollow-Up StudiesGenotypeHaplotypesHIV-1HIV InfectionsHumansInterleukinsIL19 protein, humanInterleukins

Identifiers

PMID25633979
PMCPMC4409473
OpenAlexW2038470947

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.