ArticleEnvironmental health perspectives2015
Lead exposure and tremor among older men: the VA normative aging study.
Article in Environmental health perspectives, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 12 citations in OpenAlex.
- Validation of in vivo toenail measurements of manganese and mercury using a portable X-ray fluorescence device.Journal of exposure science & environmental epidemiology · 2022Article
- Comparison of bone lead measured via portable x-ray fluorescence across and within bones.Environmental research · 2019Article
- Childhood lead biokinetics and associations with age among a group of lead-poisoned children in China.Journal of exposure science & environmental epidemiology · 2019Article
- Bone lead levels in an environmentally exposed elderly population in shanghai, China.The Science of the total environment · 2018Article
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Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundTremor is one of the most common neurological signs, yet its etiology is poorly understood. Case-control studies suggest an association between blood lead and essential tremor, and that this association is modified by polymorphisms in the δ-aminolevulinic acid dehydrogenase (ALAD) gene.
objectiveWe aimed to examine the relationship between lead and tremor, including modification by ALAD, in a prospective cohort study, using both blood lead and bone lead-a biomarker of cumulative lead exposure.
methodsWe measured tibia (n = 670) and patella (n = 672) bone lead and blood lead (n = 807) among older men (age range, 50-98 years) in the VA Normative Aging Study cohort. A tremor score was created based on an approach using hand-drawing samples. ALAD genotype was dichotomized as ALAD-2 carriers or not. We used linear regression adjusted for age, education, smoking, and alcohol intake to estimate the associations between lead biomarkers and tremor score.
resultsIn unadjusted analyses, there was a marginal association between quintiles of all lead biomarkers and tremor scores (p-values < 0.13), which did not persist in adjusted models. Age was the strongest predictor of tremor. Among those younger than the median age (68.9 years), tremor increased significantly with blood lead (p = 0.03), but this pattern was not apparent for bone lead. We did not see modification by ALAD or an association between bone lead and change in tremor score over time.
conclusionOur results do not strongly support an association between lead exposure and tremor, and suggest no association with cumulative lead biomarkers, although there is some suggestion that blood lead may be associated with tremor among the younger men in our cohort.
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