ArticleClinical research in cardiology : official journal of the German Cardiac Society2015
Electrophysiological and electrocardiographic predictors of ventricular arrhythmias originating from the left ventricular outflow tract within and below the coronary sinus cusps.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03258112 (Safety and Efficacy of Catheter Ablation of Idiopathic Ventricular Arrhythmias Arising From Cardiac Outflow Tracts), which is not on this map. Cited by 6 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Safety and Efficacy of Catheter Ablation of Idiopathic Ventricular Arrhythmias Arising From Cardiac Outflow Tracts
Who cites it
6 citing papers in PubMed, 18 citations in OpenAlex.
- The value of QRS onset of the outflow tract PVC in V1 and V2 leads recorded in fourth, third, and second intercostal spaces to differentiate main origins of premature ventricular contraction-A prospective cohort study.Health science reports · 2022Article
- Electrophysiological properties and involvement of anatomical factors for the prediction of intramural origin in patients with ventricular tachyarrhythmia arising from the left ventricular outflow tract.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2022Article
- [Premature ventricular contractions and tachycardia in a structurally normal heart : Idiopathic PVC and VT].Herzschrittmachertherapie & Elektrophysiologie · 2019Article
- Safety and efficacy in ablation of premature ventricular contraction: data from the German ablation registry.Clinical research in cardiology : official journal of the German Cardiac Society · 2017Article
- Outflow tract ventricular arrhythmia originating from the aortic cusps: our approach for challenging ablation.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2016Article
- Association between ventricular arrhythmias and myocardial mechanical dispersion assessed by strain analysis in patients with nonischemic cardiomyopathy.Clinical research in cardiology : official journal of the German Cardiac Society · 2015Article
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Authors and funding
15 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsVentricular arrhythmias (VAs) from the left ventricular outflow tract (LVOT) can originate from within or below the aortic sinus of valsalva (ASV). Mapping and ablation below the ASV is challenging and there are limited data predicting VA origins using electrocardiographic and electrophysiological features.
methodsThirty-four patients (56.7 ± 15.2 years; 19 males) with symptomatic VAs were analyzed. VA origins were determined by successful ablation. Patients were classified into 2 groups (group 1, VAs within the ASV; group 2, VAs below the ASV). Local activation and QRS morphology were compared between these 2 groups.
resultsTwelve patients were classified as group 1 and 22 as group 2. Presystolic potentials (PPs) during VAs were present in 11 patients (91 %) in group 1 and 3 (13 %) in group 2. S-wave amplitude and duration in lead I were lower and shorter in group 1 vs. group 2, respectively. Q-wave aVL/aVR ratio (Q-aVL/aVR) was smaller in group 1 vs. group 2. No group 1 patients had Q-aVL/aVR >1.45. PPs in the ASV was the strongest independent predictor for VAs originating within the ASV (OR: 30.003, P = 0.006).
conclusionDeeper and longer S-waves in lead I and Q-aVL/aVR >1.45 suggest VAs originating below the ASV. Local PPs strongly suggest an origin within the ASV. ECG characteristics combined with local PPs can be a practical guide for ablating LVOT-VAs.
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