Evidence map›Paper›PMID 25633131›Full record

ArticleScientific reports2015

Synechococcus elongatus UTEX 2973, a fast growing cyanobacterial chassis for biosynthesis using light and CO₂.

Jingjie Yu, Michelle Liberton, Paul F Cliften, Richard D Head, Jon M Jacobs, Richard D Smith, David W Koppenaal, Jerry J Brand, Himadri B Pakrasi

Abstract read
In one paragraph

Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 162 papers.

0numbers the graph read from it
0cells of the map it votes in
162citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

162 citing papers in PubMed.

  1. Cyanobacterial conversion of COChemical science · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Toward Sustainability: Intensification of Light-Driven Whole Cell Biocatalysis.Chembiochem : a European journal of chemical biology · 2026
    Review
  9. EnhancedMarine drugs · 2026
    Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Mutations in the circadian cycle drive adaptive plasticity in cyanobacteria.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

102 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jingjie YuDepartment of Biology, Washington University, St. Louis, MO 63130.
Michelle LibertonDepartment of Biology, Washington University, St. Louis, MO 63130.
Paul F CliftenGenome Technology Access Center, Washington University School of Medicine, St. Louis, MO 63110.
Richard D HeadGenome Technology Access Center, Washington University School of Medicine, St. Louis, MO 63110.
Jon M JacobsPacific Northwest National Laboratory, Richland, WA 99352.
Richard D SmithPacific Northwest National Laboratory, Richland, WA 99352.
David W KoppenaalPacific Northwest National Laboratory, Richland, WA 99352.
Jerry J BrandUTEX The Culture Collection of Algae, University of Texas at Austin, TX 78712.
Himadri B PakrasiDepartment of Biology, Washington University, St. Louis, MO 63130.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Photosynthetic microbes are of emerging interest as production organisms in biotechnology because they can grow autotrophically using sunlight, an abundant energy source, and CO₂, a greenhouse gas. Important traits for such microbes are fast growth and amenability to genetic manipulation. Here we describe Synechococcus elongatus UTEX 2973, a unicellular cyanobacterium capable of rapid autotrophic growth, comparable to heterotrophic industrial hosts such as yeast. Synechococcus UTEX 2973 can be readily transformed for facile generation of desired knockout and knock-in mutations. Genome sequencing coupled with global proteomics studies revealed that Synechococcus UTEX 2973 is a close relative of the widely studied cyanobacterium Synechococcus elongatus PCC 7942, an organism that grows more than two times slower. A small number of nucleotide changes are the only significant differences between the genomes of these two cyanobacterial strains. Thus, our study has unraveled genetic determinants necessary for rapid growth of cyanobacterial strains of significant industrial potential.

Indexed as

Biosynthetic PathwaysLightCarbon DioxideChromosome MappingGenome, BacterialINDEL MutationMolecular Sequence DataOpen Reading FramesPolymorphism, Single NucleotideProteomicsSynechococcusTime FactorsCarbon Dioxide

Identifiers

PMID25633131
PMCPMC5389031

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.