Evidence map›Paper›PMID 25633098›Full record

SynthesisMolecular neurobiology2016

CLU rs9331888 Polymorphism Contributes to Alzheimer's Disease Susceptibility in Caucasian But Not East Asian Populations.

Shuyan Zhang, Xuling Li, Guoda Ma, Yongshuai Jiang, Mingzhi Liao, Rennan Feng, Liangcai Zhang, Jiafeng Liu, Guangyu Wang, Bin Zhao and 3 more

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Molecular neurobiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 5 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 5 syntheses or guidelines pooled it, 40 citations in OpenAlex.

  1. Association between CLU gene rs11136000 polymorphism and Alzheimer's disease: an updated meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Shuyan ZhangDepartment of Neurology, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, China.
Xuling LiDepartment of Neurology, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, China.
Guoda MaInstitute of Neurology, Guangdong Medical College, Zhanjiang, 524001, China.
Yongshuai JiangCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
Mingzhi LiaoCollege of Life Science, Northwest A&F University, Yangling, Shaanxi, China.
Rennan FengDepartment of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, China.
Liangcai ZhangDepartment of Statistics, Rice University, Houston, TX, USA.
Jiafeng LiuDepartment of Neurology, The First Hospital of Harbin, Harbin, China.
Guangyu WangDepartment of Gastrointestinal Medical Oncology, The Affiliated Tumor Hospital of Harbin Medical University, Harbin, China.
Bin ZhaoInstitute of Neurology, Guangdong Medical College, Zhanjiang, 524001, China.
Qinghua JiangSchool of Life Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang, 150001, China. qhjiang@hit.edu.cn.
Keshen LiInstitute of Neurology, Guangdong Medical College, Zhanjiang, 524001, China. keshenli2012@163.com.
Guiyou LiuGenome Analysis Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Xiqi Dao 32, Tianjin Airport Economic Area, Tianjin, 300308, China. liuguiyou1981@163.com.
Harbin Medical University · CNGuangdong Medical College · CNChinese Academy of Sciences · CNHarbin Institute of Technology · CNNorthwest A&F University · CNRice University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Large-scale genome-wide association studies (GWAS) identified three single nucleotide polymorphisms rs11136000, rs2279590, and rs9331888 in CLU gene to be significantly associated with Alzheimer's disease (AD) in Caucasian ancestry. Both rs11136000 and rs2279590 variants were successfully replicated in Asian population. However, previous studies reported either a weak association or no association between rs9331888 polymorphism and AD in Asian population. Here, we searched the PubMed, AlzGene, and Google Scholar databases. We selected 12 independent studies that evaluated the association between the rs9331888 polymorphism and AD using a case-control design. Using an additive model, we did not identify significant heterogeneity among these 12 studies. We observed significant association between rs9331888 polymorphism and AD in pooled populations (P = 2.26E - 07, odds ratio (OR) = 1.10, 95% confidence interval (CI) 1.06-1.14). In subgroup analysis, we did not identify significant heterogeneity in both Asian and Caucasian populations. We identified significant association in Caucasian population (P = 1.67E - 08, OR = 1.13, 95% CI 1.08-1.18) but not in East Asian population (P = 0.49, OR = 1.02, 95% CI 0.96-1.10).

Indexed as

Polymorphism, Single NucleotideAllelesAlzheimer DiseaseAsian PeopleCase-Control StudiesClusterinGene FrequencyGenetic Predisposition to DiseaseHumansOdds RatioWhite PeopleCLU protein, humanClusterinAlzheimer’s diseaseGenome-wide association studies (GWAS)Single nucleotide polymorphisms

Identifiers

PMID25633098
OpenAlexW2069554834

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.